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Dr. Alok Srivastava MD, FRACP, FRCPA, FRCP

Senior Professor

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An alumnus of CMC, Vellore, Dr. Alok Srivastava has helped build the comprehensive adult and pediatric haematology service and teaching programs at this institution over the last three decades. He is a founder teacher for the DM haematology program in India. His research interests have been in hematopoietic stem cell transplantation (HSCT) and hemostasis disorders. Over the last 12 years, he has been responsible for establishing the Centre for Stem Cell Research, Vellore as a translational unit of the Institute of Stem Cell Science and Regenerative Medicine as a collaboration between this institute and CMC, Vellore with the Department of Biotechnology, Government of India. The focus of his current research is the development of gene therapy for hereditary hematological disorders with several international collaborations. He is also working with several colleagues in different departments of the CMC, Vellore to establish the first large comprehensive control program for the major haemoglobin disorders in India in the collaboration the state government in Odisha.

Career Interests
Career Interests

His research interests have been in hematopoietic stem cell transplantation (HSCT) and hemostasis disorders. Apart from the building the largest HSCT service in the country, his particular research interest was in improving outcomes of HSCT for thalassemia major by evaluating the pharmacokinetics and pharmacogenetics of drugs used for conditioning. He has been instrumental in establishing the Indian Stem Cell Transplant registry 15 years ago and continues to coordinates its activities. Over the last 12 years, he has been responsible for establishing the Centre for Stem Cell Research, Vellore as a translational unit of the Institute of Stem Cell Science and Regenerative Medicine as a collaboration between these two institutes and the Department of Biotechnology, Government of India. At CSCR, the focus is on developing various novel therapies towards for regenerative medicine. The focus of current research is the development of gene therapy for hereditary hematological disorders such as the major haemoglobin disorders – thalassemia and sickle cell disease with the help of several major international collaborations to bring that technology to the country. In parallel, he is also working with several colleagues in different departments of the CMC, Vellore to establish the first large comprehensive control program for the major haemoglobin disorders in India in the collaboration the state government in Odisha. http://www.cscr.in/dr-alok-srivastava/

In the field of haemostasis, over the last two decades, Dr. Srivastava has developed CMC, Vellore into a centre providing one of the most comprehensive services for patients with hereditary bleeding disorders in the world extending from the full range of clinical services from multidisciplinary clinical management including surgeries to genetic diagnosis for carrier detection and pre-natal detection of these diseases. His group has evaluated the genetics of one of the largest cohorts of such patients in the world. This was particularly necessary given the high prevalence of these conditions in Southern India with a high rate of consanguineous marriages resulting in large numbers of patients with these serious hereditary recessive disorders. It is also the centre which trains the largest number of people every year in the management of patients with bleeding disorders. More than 100 publications have resulted from the research in this field. Current effort is also on developing gene therapy as a cure for these diseases particularly severe haemophilia with both adeno associated viral vectors as well as lenti viral vectors. ​

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