Dr. Biju George – Department of Haematology

Dr. Biju George MBBS, MD, DM

Professor

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Career Interests Research Publications Bio data

Career Interests

I am a Clinician scientist involved in the management of patients with haematological disorders for the past 17 years. I completed my sub-specialty training (DM) in Clinical Haematology in 2002 at CMC Vellore under the guidance of Dr.MammenChandy. My thesis for my DM in Clinical Haematology was studying the Profile of Infections in patients undergoing stem cell transplantation. After completion of my training, I have been involved in setting up protocols for the diagnosis and management of various infections following chemotherapy and stem cell transplantation. My keen interest has been in the management of various bone marrow failure disorders (both congenital and acquired). This has helped in developing a new conditioning protocol for patients with aplastic anaemia (Fludarabine + Cyclophosphamide) which has now become the standard around the country. I have subsequently studied the use of post transplant Cyclophosphamide (PTCy) to prevent graft versus host disease in patients with aplastic anaemia and the good results shown in phase II studies has helped in developing a multicentre randomized controlled trial in India which will start in the next few months. We have also developed specialized protocols for transplantation in congenital bone marrow failure disorders such as Fanconi anaemia. Recently, we initiated a DBT funded study to look at the biology of aplastic anaemia in India especially studying telomere biology. I had the opportunity to spend 3 years (2007 – 2010) in the Haematology department at Westmead Adults Hospital in Sydney Australia under the guidance of Dr. Mark Hertzberg and Dr. David Gottlieb where I received valuable experience in alternate donor transplants (matched unrelated donor and haplo-identical transplants). This experience has helped me in initiating the Haplo-identical transplant programme using post transplant Cyclophosphamide (PTCy) at CMC Vellore in 2010 and we have completed more than 200 haplo-identical transplants. Moving forward, I would like to focus on developing cellular therapy for the management of infections and treatment of refractory malignancies.

Areas of Clinical and Laboratory Research

Aplastic Anaemia
Fanconi Anaemia
Myelodysplastic syndromes
Post transplant Infections
Alternate donor transplants
Supportive Care
Cellular therapy

Reviewer of papers submitted to the following journals

Aplastic Anaemia
British Journal of Haematology
Biology of Blood and Marrow Transplantation
Bone Marrow Transplantation
Paediatric Transplantation
Annals of Transplantation
Haematologica
Journal of Hematology and Oncology
European Journal of Haematology
Infectious Diseases
Indian Journal of Hematology and Blood Transfusion
Indian Journal of Medical Research
National Medical Journal of India
Cardiovascular and Haematological disorders – Drug targets

Research

Clinical

Cyclophosphamide as graft versus host disease (GVHD) prophylaxis in patients undergoing allogeneic stem cell transplantation for aplastic anaemia (AA) – Interventional study – CTRI/2010/091/001480 – Completed.
Study of addition of fludarabine to the standard regimen of Anti-thymocyte globulin (ATG) and cyclosporine in patients with aplastic anaemia – CTRI/2014/06/004676 – Ongoing.
Cytomegalovirus reactivation in Bone Marrow Transplant patients with use of Ganciclovir – CTRI/2014/03/004483 – Completed.
Meloxicam in combination with Colony stimulating factor (G-CSF) will improve mobilization rates in patients undergoing mobilization for autologous stem cell transplantation – CTRI/2014/06/004671 – Completed.
Impact of antifungal prophylaxis. A prospective, multicenter, observational study in India (MISFIC). CTRI/2014/04/004544 – Completed.
Leflunomide to prevent Cytomegalovirus infection in Bone marrow transplantation – CTRI/2017/06/008872 – Ongoing.
A randomized trial comparing Calphorinz solution with Chlorhexidene solution to prevent mucositis in patients undergoing transplantation – CTRI/2017/07/009007 – Ongoing.
SOAR Trial – A two-part study: Interventional phase II single-arm trial to assess efficacy and safety of Eltrombopag combined with cyclosporine as first line therapy in patients with severe acquired aplastic anemia, and an extension with up to 60-months follow-up – CTRI/2017/06/008898 –Ongoing
Pharmacokinetic and clinical study on the use of generic Busulfan [Bufatas] in patients undergoing hematopoietic stem cell transplantation – Completed
REACH 3 – A Phase III randomized multi-centre study of ruxolitinib vs. best available therapy in patients with corticosteroid-refractory chronic graft vs host disease after allogenic stem cell transplantation– CTRI/2017/09/009931 CTRI – Ongoing
A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent Randomized trial – CTRI/2018/06/014445 – Ongoing.
Randomized, Assessor-Blind, Multicentre, Parallel Group, Two Arms, Clinical Study to Assess the Efficacy, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Safety of Rituximab (Test Product, Zydus) in comparison with Rituximab (Reference Product, Roche/Genentech) in Patients with Diffuse Large B Cell Lymphoma (DLBCL) – CTRI/2018/07/014885 – Ongoing.

Laboratory

Role of telomere biology in patients with aplastic anemia – DBT funded study – Ongoing

Publications

The details of my citations and publications can be accessed at

https://scholar.google.com/citations?hl=en&user=tR-kqPEAAAAJ

My publications for the past 5 years (2013 – 2018) are as follows

Bilmon IA, Kwan J, Gottlieb D, Kerridge I, McGurgan M, Huang G, George B, Hertzberg M, Bradstock KF. Haploidentical bone marrow transplants for hematological malignancies using non-myeloablative conditioning therapy and post-transplant immunosuppression with cyclophosphamide: results from a single Australian centre. Intern Med J. 2013 Feb 43(2): 191 – 6.
Desire S, Mohanan EP, George B, Mathews V, Chandy M, Srivastava A, Balasubramanian P. A rapid & sensitive liquid chromatography- tandem mass spectrometry method for the quantitation of busulfan levels in plasma & application for routine therapeutic monitoring in haematopoietic stem cell transplantation. Indian J Med Res. 2013 Apr; 137(4): 777-784.
Mathews V, George B, Viswabandya A, Abraham A, Ahmed R, Ganapule A, Sindhuvi E, Lakshmi KM, Srivastava A. Improved Clinical Outcomes of High Risk β Thalassemia Major Patients Undergoing a HLA Matched Related Allogeneic Stem Cell Transplant with a Treosulfan Based Conditioning Regimen and Peripheral Blood Stem Cell Grafts. PLoS One 2013 Apr 26; 8(4): e61637.
Ayas M, Saber W, Davies SM, Harris RE, Hale GA, Socie G, Lerademacher J, Thakar M, Deeg HJ, Al-Seraihy A, Battiwalla M, Camitta BM, Olsson R, Bajwa RS, Bonfim CM, Pasquini R, Macmillan ML, George B, Copelan EA, Wirk B, Al Jefri A, Fasth AL, Guinan EC, Horn BN, Lewis VA, Slavin S, Stepensky P, Bierings M, Gale RP. Allogeneic Hematopoietic Cell Transplantation for FanconiAnemia in Patients WithPretransplantation Cytogenetic Abnormalities, Myelodysplastic Syndrome, or Acute Leukemia. J ClinOncol. 2013 May 1; 31(13): 1669-76.
Sumitha E, Jayandharan GR, Arora N, Abraham A, David S, Sankari Devi G, Shenbagapriya P, Nair SC, George B, Mathews V, Chandy M, Viswabandya A, Srivastava A. Molecular basis of quantitative fibrinogen disorders in 27 patients from India.Haemophilia. 2013 July; 19(4): 611-8.
Foran JM, Pavletic SZ, Logan BR, Agovi-Johnson MA, Pérez WS, Bolwell BJ, Bornhäuser M, Bredeson CN, Cairo MS, Camitta BM, Copelan EA, Dehn J, Gale RP, George B, Gupta V, Hale GA, Lazarus HM, Litzow MR, Maharaj D, Marks DI, Martino R, Maziarz RT, Rowe JM, Rowlings PA, Savani BN, Savoie ML, Szer J, Waller EK, Wiernik PH, Weisdorf DJ. Unrelated donor allogeneic transplantation after failure of autologous transplantation for acute myeloid leukemia: a study from the CIBMTR. Biol Blood Marrow Transplant 2013 July; 19(7): 1102-8.
RekhaAthiyarath, NeerajArora, Francisco Fuster, Robert Schwarzenbacher, Rayaz Ahmed, Biju George, MammenChandy, AlokSrivastava, Ana M. Rojas, Mayka Sanchez, Eunice S. Edison. Two novel missense mutations in iron transport protein transferrin causing hypochromic microcytic anaemia and haemosiderosis: molecular characterization and structural implications. Br J Hematol2013 Nov; 163(3): 404-7.
Lee SJ, Storer B, Wang H, Lazarus HM, Waller EK, Isola LM, Klumpp TR, Umejiego JB, Savani BN, Loren AW, Cairo MS, Camitta BM, Cutler CS, George B,Khoury HJ, Marks DI, Rizzieri DA, Copelan EA, Gupta V, Liesveld JL, Litzow MR, Miller AM, Shouten HC, Gale RP, Cahn J-Y, Weisdorf DJ. Providing personalized prognostic information for adult leukemia survivors.Biol Blood Marrow Transplant 2013 Nov; 19(11): 1600-7.
George B, Mathews V, Lakshmi KM, Melinkeri S, Sharma A, Viswabandya A, Sharma S, Das S, Ahmed R, Abraham A, Nair V, Apte S, Chandy M, Srivastava A. The use of a fludarabine based conditioning regimen in patients with severe aplastic anemia – a retrospective analysis from three Indian centers. Clin Transplant. 2013 Nov; 27(6): 923-9.
Bryant A, Nivison-Smith I, Pillai ES, Kennedy G, Kalff A, Ritchie D, George B, Hertzberg M, Patil S, Spencer A, Fay K, Cannell P, Berkahn L, Doocey R, Spearing R, Moore J. FludarabineMelphalan reduced-intensity conditioning allotransplanation provides similar disease control in lymphoid and myeloid malignancies: analysis of 344 patients. Bone Marrow Transplant.2014 Jan; 49(1): 17-23.
Warlick SD, Paulson K, Brazauskas R, Zhong X, Miller AM, Camitta BM, George B, Savani BN, Ustun C, Marks DI, Waller EK, Baron F, Freytes CO, Socie G, Akpek G, Schouten HC, Lazarus HM, Horwitz EM, Koreth J, Cahn JY, Bornhauser M, Seftel M, Cairo MS, Laughlin MJ, Sabloff M, Ringdén O, Gale RP, Kamble RT, Vij R, Gergis U, Mathews V, Saber W, Chen YB, Liesveld JL, Cutler CS, Ghobadi A, Uy GL, Eapen M, Weisdorf DJ, Litzow MR. Effect of post remission therapy prior to reduced intensity conditioning allogeneic transplantation for acute myeloid leukemia in first complete remission. Biol Blood Marrow Transplant.2014 Feb; 20(2): 202-8.
S. Saheer, BalamugeshThangakunam, DevasahayamJesudas Christopher, Biju George. Lenalidomide-induced diffuse alveolar haemorrhage. Lung India Feb 17; 2014; 31: 90-91.
Abraham A, Karathedath S, Varatharajan S, Markose P, Chendamarai E, Jayavelu AK, GeorgeB, Srivastava A, Mathews V, Balasubramanian P. ABCB6 RNA expression in leukemias-expression is low in acute promyelocyticleukemia and FLT3-ITD-positive acute myeloid leukemia. Ann Hematol. 2014 Mar; 93(3): 509-12.
Abraham A, George B, Ahmed R, Viswabandya A, Mathews V, Lakshmi KM, Srivastava VM, Chandy M, Srivastava A. Outcome of treatment with a low cost protocol in adults with T cell acute lymphoblastic leukaemia in a tertiary care centre in India.Leuk Lymphoma 2014 Apr; 55(4): 947-920.
Abraham A, Karathedath S, Kumaraswamy V, Jayavelu AK, M S, Srivastava VM, Zhang W, Zhou T, George B,Srivastava A, Mathews V, Balasubramanian P. Novel NPM1 mutation in the 3′-untranslated region identified in two patients with acute myeloid leukemia. Leuk Lymphoma. 2014 Jun; 55(6): 1421-4.
Abraham A, Karathedath S, Kumaraswamy V, Jayavelu AK, Mani S, SrivastavaVM,Zhang W, Zhou T, George B, Srivastava A, Mathews V, Balasubramanian P. Novel NPM1mutation in the 3′-untranslated region identified in two patients with acute myeloid leukemia. Leuk Lymphoma. 2014 Jun; 55(6): 1421-4.
Athiyarath R, George B, Mathews V, Srivastava A, Edison ES. Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in β-thalassemia.Ann Hematol. 2014 Dec; 93(12): 2093-5.
Senapati J, Devasia AJ, David S, Manipadam MT, Nair S, Jayandharan GR, George B. Diffuse large B cell lymphoma in Wiskott-Aldrich syndrome: a case report and review of literature. Indian J Hematol Blood Transfus. 2014 Sep; 30 (Suppl1): 309-13.
George L, Mathews V, George B, Thomas M, Pulimood SA. Generalized pustular psoriasis following allogeneic stem cell transplantation.ClinExpDermatol. 2015 Mar; 40(2): 160 – 162.
Senapati J, Devasia AJ, Alex AA, George B. Early T cell precursor lymphoid blast crisis of chronic myeloid leukemia – A novel transformation.HematolOncol Stem Cell Ther. 2015 Mar 8(1): 43-46.
Athiyarath R, George B, Abraham A, Viswabandya A, Srivastava A, Edison ES. Genetic modifiers of secondary iron overload in beta thalassemia major. Blood Cells Mol Dis. 2015 Mar; 54(3): 242 – 43.
Arora N, Nair S, Pai R, Nair S, Ahmed R, Abraham A, Viswabandya A, George B, Balasubramanian P, Srivastava A, Mathews V. V-raf murine sarcoma viral oncogene homolog B (BRAF) mutations in hairy cell leukaemia. Indian J PatholMicrobiol. 2015 Jan-Mar; 58(1): 62-5.
Chendamarai E, Ganesan S, Alex AA, Kamath V, Nair SC, Nellickal AJ, Janet NB, Srivastava V, Lakshmi KM, Viswabandya A, Abraham A, Aiyaz M, Mullapudi N, Mugasimangalam R, Padua RA, Chomienne C, Chandy M, Srivastava A, George B, Balasubramanian P, Mathews V. Comparison of newly diagnosed and relapsed patients with acute promyelocyticleukemia treated with arsenic trioxide: insight into mechanisms of resistance. PLoS One. 2015 Mar 30; 10(3): e0121912. doi: 10.1371/journal.pone.0121912.
George B, Mathews V, Viswabandya A, Abraham A, Ganapule A, Fouzia NA, Korula A, Lakshmi KN, Chandy M, Srivastava A. Immunosuppressive Therapy and Bone Marrow Transplantation for Aplastic Anaemia–The CMC Experience. J Assoc Physicians India. 2015 Mar; 63(3 Suppl): 36-40.
Philip C, George B, Ganapule A, Korula A, Jain P, Alex AA, Lakshmi KM, Sitaram U, Abubacker FN, Abraham A, Viswabandya A, Srivastava VM, Srivastava A, Balasubramanian P, Mathews V. Acute myeloid leukaemia: challenges and real world data from India. Br J Haematol. 2015 Jul; 170(1): 110-7.
Athiyarath R, Shaktivel K, Abraham V, Singh D, Bondu JD, Chapla A, George B, Srivastava A, Edison ES. Association of genetic variants with response to iron supplements in pregnancy. Genes Nutr. 2015 Jul; 10(4): 474.
Abraham A, Varatharajan S, Karathedath S, Philip C, Lakshmi KM, Jayavelu AK, Mohanan E, Janet NB, Srivastava VM, Shaji RV, Zhang W, Abraham A, Viswabandya A, George B,Chandy M, Srivastava A, Mathews V, Balasubramanian P. RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia. Pharmacogenomics. 2015 Jul; 16(8): 877-90.
Deshpande P, Kamalanathan N, Sampath E, George B, Shaji RV, Edison ES. Characterization of Clinical and Laboratory Profiles of the Deletional α2-Globin Gene Polyadenylation Signal Sequence (AATAAA > AATA- -) in an Indian Population.Hemoglobin. 2015; 39(6): 415-8.
Rose W, Veeraraghavan B, George B. Bloodstream infections in children with febrile neutropenia: Isolates and their antimicrobial susceptibility profile. Indian J Cancer. 2015 Oct-Dec; 52(4): 495-6.
Jayasree D, Shaji RV, George B, Mathews V, Srivastava A, Edison ES. Clinical, Hematological and Molecular Analysis of Homozygous Hb E (HBB: c.79G > A) in the Indian Population. Hemoglobin. 2016; 40(1): 16-9.
Kiruthiga Kala Gnanasekaran, Mary P. Chacko, Marie Therese Manipadam, M. S. Bindra, Biju George, Vivi M. Srivastava. Acute monoblasticleukemia with abnormal eosinophils and inversion (16): A rare entity. Indian Journal of Pathology and Microbiology 2016 Jan-Mar; 59(1): 104-6.
Pasquini MC, Zhang MJ, Medeiros BC, Armand P, Hu ZH, Nishihori T, Aljurf MD, Akpek G, Cahn JY, Cairo MS, Cerny J, Copelan EA, Deol A, Freytes CO, Gale RP, Ganguly S, George B, Gupta V, Hale GA, Kamble RT, Klumpp TR, Lazarus HM, Luger SM, Liesveld JL, Litzow MR, Marks DI, Martino R, Norkin M, Olsson RF, Oran B, Pawarode A, Pulsipher MA, Ramanathan M, Reshef R, Saad AA, Saber W, Savani BN, Schouten HC, Ringdén O, Tallman MS, Uy GL, Wood WA Jr, Wirk B, Pérez WS, Batiwalla M, Weisdorf DJ. Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies.Biol Blood Marrow Transplant. 2016 Feb; 22(2): 248-57.
Kumar R, Kimura F, Ahn KW, Hu ZH, Kuwatsuka Y, Klein JP, Pasquini M, Miyamura K, Kato K, Yoshimi A, Inamoto Y, Ichinohe T, Wood WA Jr, Wirk B, Seftel M, Rowlings P, Marks DI, Schultz KR, Gupta V, Dedeken L, George B, Cahn JY, Szer J, Lee JW, Ho AY, Fasth A, Hahn T, Khera N, Dalal J, Bonfim C, Aljurf M, Atsuta Y, Saber W. Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions. Biol Blood Marrow Transplant. 2016 May; 22(5): 932-40.
George L, Peter D, Chopra M, George B, Abraham A, Mathews V, Srivastava A, Pulimood SA. Efficacy of narrow band UVB in the treatment of cutaneous GvHD: an Indian experience. Bone Marrow Transplant. 2016 July; 51(7): 988-90.
Deshpande P, Kathirvel K, Alex AA, Korula A, George B, Shaji RV, Mathews V. Leukocyte Adhesion Deficiency-I: Clinical and Molecular Characterization in an Indian Population. Indian J Pediatr. 2016 August; 83(8): 799-804.
Garge S, Keshava S, Moses V, Mammen S, Ahmed M, Koshy G, Cherian V, Manasseh N, George B, Mathews V, Abraham A, Viswabandya A, Srivastava A, Gibikote S. Role of endovascular embolisation in treatment of acute bleeding complications in haemophilia patients. Br J RadiolAugust 2016; 89(1064): 20151064.
Ballen K, Ahn KW, Chen M, Abdel-Azim H, Ahmed I, Aljurf M, Antin J, Bhatt AS, Boeckh M, Chen G, Dandoy C, George B, Laughlin MJ, Lazarus HM, MacMillan ML, Margolis DA, Marks DI, Norkin M, Rosenthal J, Saad A, Savani B, Schouten HC, Storek J, Szabolcs P, Ustun C, Verneris MR, Waller EK, Weisdorf DJ, Williams KM, Wingard JR, Wirk B, Wolfs T, Young JH, Auletta J, Komanduri KV, Lindemans C, Riches ML. Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 Sep; 22(9): 1636-45.
Ahmed R, Devasia AJ, Viswabandya A, Lakshmi KM, Abraham A, Karl S, Mathai J, Jacob PM, Abraham D, Srivastava A, Mathews V, George B. Long-term outcome following splenectomy for chronic and persistent immune thrombocytopenia (ITP) in adults and children. Ann Hematol. 2016 Sep; 95(9): 1429-34.
Philip C, George B, Korula A, Srivastava A, Balasubramanian P, Mathews V. Treatment rates of paediatric acute myeloid leukaemia: a view from three tertiary centres in India – response to Gupta et al. Br J Haematol. 2016 Oct; 175(2): 347-49.
Deshpande PA, Srivastava VM, Mani S, Anandhan S, Meena J, Abraham A, Viswabandya A, George B,Srivastava A, Mathews V, Balasubramanian P. Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. Leuk Lymphoma. 2016 Oct; 57(10): 2481-4.
Devasia AJ, Irodi A, George B. Broncho-Pericardial Fistula leading to pneumo-pericardium following Allogeneic Stem Cell Transplantation.Indian J Pediatr. 2016 October; 83(10): 1206-7.
George A, Peter D, Pulimood S, Manipadam MT, George B, Paul MJ, Thomas JK. Rapidly progressing necrotic ulcerations and sinuses in specific cutaneous Hodgkin’s disease. Indian Dermatol Online J. 2016 Sep-Oct; 7(5): 436-438.
Pragasam AK, Yesurajan F, Doss C GP, George B, DevangaRagupathi NK, Walia K, Veeraraghavan B. Draft Genome Sequence of Extremely Drug-Resistant Pseudomonas aeruginosa (ST357) Strain CMC_VB_PA_B22862 Isolated from a Community-Acquired Bloodstream Infection. Genome Announc.2016 Oct 20; 4(5).pii: e01092-16.
Varatharajan S, Panetta JC, Abraham A, Karathedath S, Mohanan E, Lakshmi KM, Arthur N, Srivastava VM, Nemani S, George B, Srivastava A, Mathews V, Balasubramanian P. Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia. Cancer ChemotherPharmacol. 2016 Nov; 78(5): 1051-1058.
Ganesan S, Alex AA, Chendamarai E, Balasundaram N, Palani HK, David S, Kulkarni U, Aiyaz M, Mugasimangalam R, Korula A, Abraham A, Srivastava A, Padua RA, Chomienne C, George B, Balasubramanian P, Mathews V. Rationale and efficacy of proteasome inhibitor combined with arsenic trioxide in the treatment of acute promyelocyticleukemia. Leukemia 2016 Nov; 30(11): 2169-78.
Mahabal G, George L, Bindra M, George B. Late-onset acute graft-versus-host disease mimicking hand, foot, and mouth disease. Indian Dermatol Online J. 2016 Nov-Dec; 7(6):509-511.
Ram M, Ramakant P, Parmar H, George B, Paul MJ. Primary Breast T cell Lymphoma involving Nipple-Areolar Complex in a Young Patient. Indian J Surg. 2016 Dec; 78(6):499-501.
Pragasam AK, Shankar C, Veeraraghavan B, Biswas I, Nabarro LE, Inbanathan FY, George B, Verghese S. Molecular Mechanisms of Colistin Resistance in Klebsiellapneumoniae Causing Bacteremia from India – A First Report. Front Microbiol. 2017 Jan 9; 7: 2135.
Varatharajan S, Abraham A, Karathedath S, Ganesan S, Lakshmi KM, Arthur N, Srivastava VM, George B, Srivastava A, Mathews V, Balasubramanian P. ATP-binding casette transporter expression in acute myeloid leukemia: association with in vitro cytotoxicity and prognostic markers. Pharmacogenomics 2017 Feb; 18(3): 235-244.
Maziarz RT, Brazauskas R, Chen M, McLeod AA, Martino R, Wingard JR, Aljurf M,
Battiwalla M, Dvorak CC, George B, Guinan EC, Hale GA, Lazarus HM, Lee JW, Liesveld JL, Ramanathan M, Reddy V, Savani BN, Smith FO, Strasfeld L, Taplitz RA, Ustun C, Boeckh MJ, Gea-Banacloche J, Lindemans CA, Auletta JJ, Riches ML. Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study. Bone Marrow Transplant. 2017 Feb; 52(2):270-278.
Ganapule A, Jain P, Nambiar FA, Korula A, Abraham A, Mammen J, George B, Mathews V, Srivastava A, Viswabandya A. Surgical procedures in patients with Glanzmann’sthrombasthenia: case series and literature review. Blood Coagul Fibrinolysis. 2017 Mar; 28(2): 171-175.
Angi M, Kamath V, Yuvarani S, Meena J, Sitaram U, Manipadam MT, Nair S, Ganapule A, Fouzia NA, Abraham A, Viswabandya A, Poonkuzhali B, George B, Mathews V, Srivastava A, Srivastava VM. The t(8;14)(q24.1;q32) and its variant translocations: A study of 34 cases. HematolOncol Stem Cell Ther. 2017 Sep; 10(3): 126 – 34.
Bharathan SP, Nandy K, Palani D, Janet A NB, Natarajan K, George B, Srivastava A, Velayudhan SR. Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconianemia by conditional complementation. Stem Cell Res. 2017 Apr; 20: 54-57.
Nemani S, Agrawal B, Danda S, George B. Gaucher Disease Presenting in an Adult with Intracerebral Bleed. J Assoc Physicians India. 2017 Apr; 65(4): 89-90.
Arun AK, Senthamizhselvi A, Mani S, Vinodhini K, Janet NB, Lakshmi KM, Abraham A, George B, Srivastava A, Srivastava VM, Mathews V, Balasubramanian P. Frequency of rare BCR-ABL1 fusion transcripts in chronic myeloid leukemia patients. Int J Lab Hematol.2017 Jun; 39(3): 235-242.
Mohanan E, Panetta JC, Lakshmi KM, Edison ES, Korula A, Fouzia NA, Abraham A, Viswabandya A, Mathews V, George B, Srivastava A, Balasubramanian P. Population pharmacokinetics of fludarabine in patients with aplastic anemia and Fanconianemia undergoing allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant.2017 Jul; 52(7):977-983.
Abbas S, Kini A, Srivastava VM, M MT, Nair SC, Abraham A, Mathews V, George B, Kumar S. Venkatraman A, Srivastava A. Coexistence of aberrant hematopoietic and stromal elements in myelodysplastic syndromes. Blood Cells Mol Dis. 2017 Jul; 66: 37-46.
Korula A, Abraham A, Abubacker FN, Viswabandya A, Lakshmi KM, Abraham OC, Rupali P, Varghese GM, Michael JS, Srivastava A, Mathews V, George B. Invasive fungal infection following chemotherapy for acute myeloid leukaemia – Experience from a developing country. Mycoses 2017 Oct; 60(10):686-691.
Kumar R, Bonfim C, George B. Hematopoietic cell transplantation for aplastic anemia. CurrOpinHematol. 2017 Nov; 24(6): 509-514.
Ganapule A, Nemani S, Korula A, Lakshmi KM, Abraham A, Srivastava A, Balasubramanian P, George B, Mathews V. Allogeneic Stem Cell Transplant for Acute Myeloid Leukemia: Evolution of an Effective Strategy in India. J Glob Oncol. 2017 Dec; 3(6):773-781.
Korula A, P N N, Devasia A, Lakshmi KM, Abraham A, Sindhuvi E, George B, Srivastava A, Mathews V. Second Hematopoietic SCT for Thalassemia Major: Improved Clinical Outcomes with a Treosulfan Based Conditioning Regimen. Biol Blood Marrow Transplant.2018 Jan; 24(1): 103-108.
Fouzia NA, Edison ES, Lakshmi KM, Korula A, Velayudhan SR, Balasubramanian P, Abraham A, Viswabandya A, George B, Mathews V, Srivastava A. Long-term outcome of mixed chimerism after stem cell transplantation for thalassemia major conditioned with busulfan and cyclophosphamide. Bone Marrow Transplant 2018 Feb; 53(2):169-174.
Mohanan E, Panetta JC, Lakshmi KM, Edison ES, Korula A, Na F, Abraham A, Viswabandya A, George B, Mathews V, Srivastava A, Balasubramanian P. Pharmacokinetics and pharmacodynamics of Treosulfan in patients with thalassemia major undergoing allogeneic hematopoietic stem cell transplantation. ClinPharmacolTher. 2018 Sep; 104(3): 575-583.
George B, PN Nisham, Devasia AJ, Kulkarni U, Korula A, Lakshmi KM, Abraham A, Srivastava A, Mathews V. Post-Transplant Cyclophosphamide (PTCY) as Sole GVHD Prophylaxis is Feasible in Patients Undergoing Peripheral Blood Stem Cell Transplantation for Severe Aplastic Anaemia Using Matched Sibling Donors. Biol Blood Marrow Transplant. 2018 Mar; 24(3): 494 – 500.
John MJ, Mathew A, Bhat S, Prabhakaran A, George B, John J. Post stem cell transplantation revaccination: A survey of the current practices in India. Vaccine 2018 Apr 12; 36(16):2176-2180.
Wood WA, Brazauskas R, Hu ZH, Abdel-Azim H, Ahmed IA, Aljurf M, Badawy S, Beitinjaneh A, George B, Buchbinder D, Cerny J, Dedeken L, Diaz MA, Freytes CO, Ganguly S, Gergis U, Almaguer DG, Gupta A, Hale G, Hashmi SK, Inamoto Y, Kamble RT, Adekola K, Kindwall-Keller T, Knight J, Kumar L, Kuwatsuka Y, Law J, Lazarus HM, LeMaistre C, Olsson RF, Pulsipher MA, Savani BN, Schultz KR, Saad AA, Seftel M, Seo S, Shea TC, Steinberg A, Sullivan K, Szwajcer D, Wirk B, Yared J, Yong A, Dalal J, Hahn T, Khera N, Bonfim C, Atsuta Y, Saber W. Country-Level Macroeconomic Indicators Predict Early Post-Allogeneic Hematopoietic Cell Transplantation Survival in Acute Lymphoblastic Leukemia: a CIBMTR Analysis. Biol Blood Marrow Transplant. 2018 Sep; 24(9): 1928 – 35.
Mahabal GD, George L, Peter D, Bindra M, Thomas M, Srivastava A, Mathews V, George B, Pulimood SA. Utility of tissue elafin as an immunohistochemical marker for diagnosis of acute skin graft-versus-host disease: a pilot study. ClinExpDermatol. 2019 Mar; 44(2): 161-68.
Alex AA, Ganesan S, Palani HK, Balasundaram N, David S, Lakshmi KM, Kulkarni UP, Nisham PN, Korula A, Devasia AJ, Janet NB, Abraham A, Srivastava A, George B, Padua RA, Chomienne C, Balasubramanian P, Mathews V. Arsenic Trioxide Enhances the NK Cell Cytotoxicity Against Acute PromyelocyticLeukemia While Simultaneously Inhibiting Its Bio-Genesis. Front Immunol. 2018 Jun 14; 9: 1357.
Elayaperumal S, Fouzia NA, Biswas A, Nair SC, Viswabandya A, George B, Abraham A, Oldenburg J, Edison ES, Srivastava A. Type-3 von Willebrand disease in India-Clinical spectrum and molecular profile. Haemophilia 2018 Nov; 24(6): 930-940.
Nemani S, Korula A, Agrawal B, Kavitha ML, Manipadam MT, Sigamani E, George B, Srivastava A, Viswabandya A, Mathews V. Peripheral T cell lymphoma: Clinico-pathological characteristics & outcome from a tertiary care centre in south India. Indian J Med Res. 2018 May; 147(5): 464-470.
Duraisamy SK, Mammen S, Lakshminarayan SKR, Verghese S, Moorthy M, George B, Kannangai R, Varghese S, Srivastava A, Abraham AM. Performance of an in-house real-time PCR assay for detecting Cytomegalovirus infection among transplant patients from a tertiary care centre.Indian J Med Microbiol. 2018 Apr-Jun; 36(2): 241-246.
Kulkarni U, Devasia AJ, Korula A, Na F, Pn N, Samoon YJ, Lakshmi KM, Abraham A, Srivastava A, Mathews V, George B. Use of Non-Cryopreserved Peripheral Blood Stem Cells Is Associated with Adequate Engraftment in Patients with Multiple Myeloma Undergoing an Autologous Transplant. Biol Blood Marrow Transplant 2018 Dec; 24(12): e31-e35.
Arun AK, Senthamizhselvi A, Hemamalini S, Edison ES, Korula A, Fouzia NA, George B, Mathews V, Balasubramanian P. Spectrum of ELANE mutations in congenital neutropenia: a single-centre study in patients of Indian origin. J ClinPathol. 2018 Dec; 71(12): 1046-1050.
Jain P, Korula A, Deshpande P, Pn N, Abu Alex A, Abraham A, Srivastava A, Janet NB, Lakshmi KM, Balasubramanian P, George B, Mathews V. Adult Acute Lymphoblastic Leukemia: Limitations of Intensification of Therapy in a Developing Country. J Glob Oncol. 2018 Sep; (4): 1-12.
Norkin M, Shaw BE, Brazauskas R, Tecca HR, Leather HL, Gea-Banacloche J, Kamble R, DeFilipp Z, Jacobsohn DA, Ringden O, Inamoto Y, Kasow K, Buchbinder D, Shaw P, Hematti P, Schears R, Badawy SM, Lazarus HM, Bhatt N, Horn B, Chhabra S, Page K, Hamilton B, Hildebrandt GC, Yared JA, Agrawal V, Beitinjaneh A, Majhail N, Kindwall-Keller T, Olsson RF, Schoemans H, Gale RP, Ganguly S, Ahmed I, Schouten HC, Liesveld J, Khera N, Steinberg A, Shah AJ, Solh M, Marks DI, Rybka W, Aljurf M, Dietz AC, Gergis U, George B, Seo S, Flowers MED, Battiwalla M, Savani BN, Riches ML, Wingard JR. Characteristics of Late Fatal Infections after Allogeneic Hematopoietic Cell Transplant. Biol Blood Marrow Transplant. 2019 Feb; 25(2): 362 – 368.
Devasia AJ, Mammen S, Korula A, Abraham A, Fouzia NA, Lakshmi KM, Abraham AM,
Srivastava A, Mathews V, George B. A low Incidence of cytomegalovirus infection following Allogeneic Hematopoietic Stem Cell Transplantation despite a high seroprevalence.Indian J Hematol Blood Transfus. 2018 Oct;34(4):636-642.
David S, Nair SC, Singh GS, Alex AA, Ganesan S, Palani HK, Balasundaram N, Lakshmi KM, Joshi A, Kannan S, Korula A, NambiatheyilAboobacker F, Abraham A, George B,Apte SJ, Srivastava A, Mathews V. Prevalence of FVIII inhibitors in severe haemophilia A patients: Effect of treatment and genetic factors in an Indian population. Haemophilia 2019 Jan; 25(1): 67 – 74.
Manesh A, Rupali P, O Sullivan M, Raj PM, Rupa V, George B, Michael JS. Mucormycosis – a clinicoepidemiological review of cases over 10 years. Mycoses 2019 Apr: 62(4): 391-398.
Kulkarni U, George B. Access to hematopoietic stem-cell transplantation in India. J Postgrad Med. 2019 Jan-Mar; 65(1): 1-4.
Yeshurun M, Weisdorf D, Rowe JM, Tallman MS, Zhang MJ, Wang HL, Saber W, de Lima M, Sandmaier BM, Uy G, Kamble RT, Cairo MS, Cooper BW, Cahn JY, Ganguly S, Camitta B, Verdonck LF, Dandoy C, Diaz MA, Savani BN, George B, Liesveld J, McGuirk J, Byrne M, Grunwald MR, Drobyski WR, Pulsipher MA, Abdel-Azim H, Prestidge T, Wieduwilt MJ, Martino R, Norkin M, Beitinjaneh A, Seo S, Nishihori T, Wirk B, Frangoul H, Bashey A, Mori S, Marks DI, Bachanova V. The impact of the graft-versus-leukemia effect on survival in acute lymphoblastic leukemia.Blood Adv. 2019 Feb 26; 3(4): 670-680.
Korula A, Devasia AJ, Fouzia NA, Nisham PN, Kulkarni U, Lakshmi KM, Abraham A, Srivastava A, Mathews V, George B. Outcomes Following Allogeneic Stem Cell transplantation Using Non-sibling Family Donors. Indian J Hematol Blood Transfus. 2019 Jan; 35(1): 43-49.
Parikh SH, Satwani P, Ahn KW, Sahr NA, Fretham C, Abraham AA, Agrawal V, Auletta JJ, Abdel-Azim H, Copelan E, Diaz MA, Dvorak CC, Frangoul HA, Freytes CO, Gadalla SM, Gale RP, George B, Gergis U, Hashmi S, Hematti P, Hildebrandt GC, Keating AK, Lazarus HM, Myers KC, Olsson RF, Prestidge T, Rotz SJ, Savani BN, Shereck EB, Williams KM, Wirk B, Pasquini MC, Loren AW. Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Transplant. JAMA Pediatr. 2019 Mar 18:e190081. doi: 10.1001/jamapediatrics.2019.0081.

Bio data

Dates	Degree	Subject	University
1986 – 1992	MBBS	Medicine	Madras Unirvesity
1995 – 1998	MD	Internal Medicine	Dr. MGR Medical University
2000 – 2002	DM	Clinical Haematology	Dr. MGR Medical University

Professional Affiliations:

Member Indian Society of Haematology and Transfusion Medicine (ISHTM)
Member American Society of Bone Marrow Transplantation (ASBMT)
Member Asia Pacific Bone Marrow Transplantation (APBMT)
Member American Society of Haematology (ASH)
Member International Society for Cellular Therapy (ISCT)
Presently
Vice Chair Asia/Africa/Australia Advisory Committee for the CIBMTR
Chair of the Working committee for Congenital Bone Marrow Failure Disorders in APBMT