Dr. Uday Prakash Kulkarni – Department of Haematology

Dr. Uday Prakash Kulkarni MD, DM

Professor

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Career Interests Research Publications Bio data

Career Interests

Career interests:

Malignant hematologic disorders
Stem cell transplantation
Cell and gene therapy
Research methodology and biostatistics

Awards:

Best oral presentation award at Haematocon 2021
Best oral presentation award at Haematocon 2019
Wellcome Trust/DBT India Alliance Early Career Fellow 2018-2023
The Tamil Nadu Dr MGR Medical University Medal in Clinical Haematology in
2016
Best oral presentation at APICON 2012
ICMR Short term studentship award in 2005 and 2006
Indian National Biology Olympiad Gold Medal in 2003
National Talent Search Scholarship in 2001

Research

I am involved in the following:

Translational research pertaining to malignant hematology and cell and gene therapy in collaboration with my laboratory and clinical colleagues
Clinical research involving investigator initiated and industry sponsored trials

Research grant:

India Alliance early career research grant (Rs 1.8 crores) for evaluation of NK cell therapy in refractory AML (2018 to 2023)

Publications

Publications list

https://scholar.google.com/citations?hl=en&user=E95zwPIAAAAJ

Kulkarni U, Arunachalam AK, Palani HK, Nair RR, Balasundaram N, Venkatraman A, Korula A, Selvarajan S, Lionel S, Balasubramanian P, Maddali M, Abraham A, George B, Mathews V. Haploidentical Natural Killer Cell Therapy as an Adjunct to Stem Cell Transplantation for Treatment of Refractory Acute Myeloid Leukemia. Cell Transplant. 2023 Jan-Dec;32:9636897231198178. doi: 10.1177/09636897231198178.
PMID: 37706453; PMCID: PMC10503284.
Kulkarni UP, Selvarajan S, Fouzia NA, Lionel S, Nair SC, Balasubramanian P, Mani T, Abraham A, George B, Mathews V. Intracranial bleeding in acute promyelocytic leukemia treated with arsenic trioxide based regimens is associated with induction mortality but not with relapse. Blood Cancer J. 2023 Jun 22;13(1):94. doi: 10.1038/s41408-023-00873-z. PMID: 37349334; PMCID: PMC10287743.
Kulkarni UP, Pai AA, Kavitha ML, Selvarajan S, Lionel S, Devasia AJ, Korula A, Fouzia NA, Sindhuvi E, Abraham A, Srivastava A, Mathews V, George B, Balasubramanian P. Endothelial Activation and Stress Index-Measured Pretransplantation Predicts Transplantation-Related Mortality in Patients with Thalassemia Major Undergoing Transplantation with Thiotepa, Treosulfan, and Fludarabine Conditioning.
Transplant Cell Ther. 2022 Jul;28(7):356.e1-356.e6. doi: 10.1016/j.jtct.2022.05.001. Epub 2022 May 9. PMID: 35550442.
Kulkarni UP, Selvarajan S, Lionel S, Prakash MA, Palani HK, Balasundaram N, Venkataraman A, Korula A, Devasia AJ, Fouzia NA, Janet NB, Nair SC, Abraham A, Mani T, Lakshmanan J, Arunachalam AK, Balasubramanian P, George B, Mathews V. Real world data with concurrent retinoic acid and arsenic trioxide for the treatment of acute promyelocytic leukemia. Blood Cancer J. 2022 Jan 31;12(1):22. doi: 10.1038/s41408-022-00619-3. PMID: 35102152.
George B, Kulkarni U, Lionel S, Devasia AJ, Aboobacker FN, Lakshmi KM, Selvarajan S, Korula A, Rose W, Varghese GM, Rupali P, V B, Michael JS, Abraham A, Abraham A, Mathews V. Haploidentical transplantation is feasible and associated with reasonable outcomes despite major infective complications – a single center experience from India. Transplant Cell Ther. 2021 Oct 1:S2666-6367(21)01262-8. doi: 10.1016/j.jtct.2021.09.020. Epub ahead of print. PMID: 34607073.
Kulkarni U, Mathews V. Evolving Chemotherapy Free Regimens for Acute Promyelocytic Leukemia. Front Oncol. 2021 Feb 25;11:621566. doi: 10.3389/fonc.2021.621566. PMID: 33718181; PMCID: PMC7947681.
Kulkarni U, Ganesan S, Alex AA, Palani H, David S, Balasundaram N, Venkatraman A, Nair SC, Thenmozhi M, Jeyaseelan L, Korula A, Devasia A, Abraham A, Janet NB, Balasubramanian P, George B, Mathews V. A phase II study evaluating the role of bortezomib in the management of relapsed acute promyelocytic leukemia treated upfront with arsenic trioxide. Cancer Med. 2020 Feb 14. doi: 10.1002/cam4.2883. [Epub ahead of print] PubMed PMID: 32059085.
Kulkarni U, George B. Access to hematopoietic stem-cell transplantation in India. J Postgrad Med. 2019 Jan-Mar;65(1):1-4. doi: 10.4103/jpgm.JPGM_391_18. PubMed PMID: 30693869; PubMed Central PMCID: PMC6380131.
Kulkarni U, Devasia AJ, Korula A, Fouzia NA, Nisham PN, Samoon YJ, Lakshmi KM, Abraham A, Srivastava A, Mathews V, George B. Clinical outcomes in multiple myeloma post-autologous transplantation – A single centre experience. Indian J Hematol Blood Transfus. 2019 Apr;35(2):215-222. doi: 10.1007/s12288-018-0989-y. Epub 2018 Jul 21. PMID: 30988555; PMCID: PMC6438994.
Kulkarni U, Devasia AJ, Korula A, Fouzia NA, Nisham PN, Samoon YJ, Lakshmi KM, Abraham A, Srivastava A, Mathews V, George B. Use of Non-Cryopreserved Peripheral Blood Stem Cells Is Associated with Adequate Engraftment in Patients with Multiple Myeloma Undergoing an Autologous Transplant. Biol Blood Marrow Transplant. 2018 Aug 22. pii: S1083-8791(18)30472-5. doi: 10.1016/j.bbmt.2018.08.007. [Epub ahead of print] PubMed PMID: 30142418.
Kulkarni U, Valson A, Korula A, Mathews V. Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis. Mediterr J Hematol Infect Dis. 2015 Jul 1;7(1):e2015043. PubMed PMID: 26185608; PubMed Central PMCID: PMC4500494.
Kulkarni UP, Gokhale YA, Raut PM, Dargad RR. An unusual cause for sicca syndrome. J Postgrad Med. 2011 Apr-Jun;57(2):129-30. PubMed PMID: 21654136.
Kulkarni UP, Karnad DR, Gogtay NJ. Genetics of warfarin response. N Engl J Med. 2008 Jun 19;358(25):2742-3. PubMed PMID: 18572454.
Kulkarni UP, Swar BD, Karnad DR, Davis S, Patwardhan AM, Kshirsagar NA, Gogtay NJ. A pilot study of the association of pharmacokinetic and pharmacodynamic parameters of warfarin with the dose in patients on long-term anticoagulation. Br J ClinPharmacol. 2008 May;65(5):787-90. Epub 2008 Feb 21. PubMed PMID: 18294321; PubMed Central PMCID: PMC2432491.
Kulkarni UP. The Bayesian clinician. J Postgrad Med. 2007 Oct-Dec;53(4):267-9. Review. PubMed PMID: 18097119.

Bio data

Education:

September 2003 to February 2008 – MBBS from Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Parel,
Mumbai (Maharashtra University of Health Sciences).
May 2009 to June 2012 – MD in General Medicine from Lokmanya Tilak Municipal Medical College, Sion, Mumbai (Maharashtra University of Health Sciences).
August 2013 to July 2016 – DM in Clinical Haematology at Christian Medical College, Vellore (The Tamil Nadu Dr MGR Medical University).

Work experience:

February 2008 to February 2009 – Internship at King Edward Memorial Hospital, Parel, Mumbai.
June 2012 to July 2012 – Senior resident in Medicine at Lokmanya Tilak Municipal Medical College, Sion, Mumbai.
August 2012 to December 2012 – Specialty Medical Officer at ESIS Hospital, Ulhasnagar, Maharashtra.
January 2013 to July 2013 – Assistant Professor in Medicine at Lokmanya Tilak Municipal Medical College, Sion, Mumbai.
September 2016 to September 2018 – Assistant Professor in Haematology, Christian Medical College, Vellore
September 2018 till September 2022 – Associate Professor in Haematology
September 2022 till date – Professor in Haematology

Professional Affiliations:

Member, Indian Society of Hematology and Blood Transfusion
Member, Indian Society for Blood and Marrow Transplantation
International Member, American Society of Hematology
Member, International Society for Cell and Gene Therapy