Research

• Mutation profile in BCR-ABL1-negative myeloproliferative neoplasms
• Role of cost-effective long amplicon based sequencing technique using NGS as a diagnostic modality in various benign inherited haematological disorders.
• Molecular characterization of triple negative myeloproliferative neoplasms (TN-MPN) by targeted next generation sequencing (NGS)
• Incidence and prognostic impact of IKZF1 deletions in B-cell precursor Acute lymphoblastic leukemia (BCP-ALL).
• Immunophenotypic characterization and analysis of outcomes of early t cell precursor (ETP) acute lymphoblastic leukemia.

• Maddali M,Arunachalam AK, Kapadia AK, Kulkarni UP, Balasubramanian P. A review on the role of Molecular Genetics in the diagnostic workup of BCR::ABL1-negative myeloproliferative neoplasms. Indian Journal of Medical and Paediatric Oncology. 2023;44(06):578–84. doi:10.1055/s-0043-1766138
• Arunachalam, A. K., Maddali, M., Janet, N. B., Aboobacker, F. N., Edison, E. S. (2022). Immunophenotype, karyotype and molecular findings in a case of ICF syndrome. Indian Journal of Hematology and Blood Transfusion. https://doi.org/10.1007/s12288-022-01596-0
• Maddali, M., Venkatraman, A., Kulkarni, U. P., Mani, S., Raj, S., Sigamani, E., Korula, A., A, F. N., Lionel, S. A., Selvarajan, S., Manipadam, M. T., Abraham, A., George, B., Mathews, V., Balasubramanian, P. (2022). Molecular characterization of triple-negative myeloproliferative neoplasms by next-generation sequencing. Annals of Hematology, 101(9), 1987–2000. https://doi.org/10.1007/s00277-022-04920-w
• Maddali, M., Kulkarni, U. P., Ravindra, N., Arunachalam, A. K., Venkatraman, A., Lionel, S., Manipadam, M. T., Devasia, A. J., Korula, A., Fouzia, N. A., Abraham, A., Srivastava, A., George, B., Balasubramanian, P., Mathews, V. (2021). Mutation profile in BCR-ABL1-negative myeloproliferative neoplasms: A single-center experience from India. Hematology/Oncology and Stem Cell Therapy. https://doi.org/10.1016/j.hemonc.2021.03.002
• Maddali, M., Kulkarni, U. P., Ravindra, N., Jajodia, E., Arunachalam, A. K., Suresh, H., Venkatraman, A., George, B., Mathews, V., Balasubramanian, P. (2020). JAK2 exon 12 mutations in cases with JAK2V617F-negative polycythemia vera and primary myelofibrosis. Annals of Hematology, 99(5), 983–989. https://doi.org/10.1007/s00277-020-04004-7
• Maddali, M., Balasubramanian, P. (2019). Applications of next generation sequencing in haematological disorders—Indian status: Updates from ISHBT 2018. Indian Journal of Hematology and Blood Transfusion, 35(1), 17–21. https://doi.org/10.1007/s12288-018-01068-4
• Arunachalam, A. K., Maddali, M., Aboobacker, F. N., Korula, A., George, B., Mathews, V., Edison, E. S. (2020). Primary immunodeficiencies in India: Molecular diagnosis and the role of next-generation sequencing. Journal of Clinical Immunology, 41(2), 393–413. https://doi.org/10.1007/s10875-020-00923-2.
• Arunachalam, A. K., Sumithra, S., Maddali, M., Fouzia, N. A., Abraham, A., George, B., Edison, E. S. (2019). Molecular characterization of G6PD deficiency: Report of three novel G6PD variants. Indian Journal of Hematology and Blood Transfusion, 36(2), 349–355. https://doi.org/10.1007/s12288-019-01205-7.

Other publications:

• Kulkarni, U., Arunachalam, A. K., Palani, H. K., Nair, R. R., Balasundaram, N., Venkatraman, A., Korula, A., Selvarajan, S., Lionel, S., Balasubramanian, P., Maddali, M., Abraham, A., George, B., & Mathews, V. (2023). Haploidentical Natural Killer Cell Therapy as an Adjunct to Stem Cell Transplantation for Treatment of Refractory Acute Myeloid Leukemia. Cell transplantation, 32, 9636897231198178. https://doi.org/10.1177/09636897231198178
• Bama Benjamin ES, Babu D, Joshi G, Rajamani BM, Nandy K, Rani S, et al. Inhibition of BCR::ABL1 tyrosine kinase activity aids in the generation of stable chronic myeloid leukemia induced pluripotent stem cells. 2023; doi:10.1101/2023.06.01.543015
• Rani S, Thamodaran V, Nandy K, Aboobacker FN, Maddali M, Rajesh P, et al. Establishment and characterization of CSCRI006-A: An induced pluripotent stem cell line generated from a patient with diamond-blackfan anemia (DBA) carrying ribosomal protein S19 (RPS19) mutation. 2023; doi:10.21203/rs.3.rs-2876104/v1
• Kulkarni, U., Arunachalam, A. K., Palani, H. K., Balasundaram, N., Venkatraman, A., Korula, A., Devasia, A. J., NA, F., Selvarajan, S., Lionel, S., Maddali, M., Abraham, A., Balasubramanian, P., George, B., Mathews, V. (2022). Haploidentical Natural Killer cell therapy as an adjunct to stem cell transplantation for refractory acute myeloid leukemia. Transplantation and Cellular Therapy, 28(3). https://doi.org/10.1016/s2666-6367(22)00445-6
• Manian, K. V., Bharathan, S. P., Maddali, M., Srivastava, V. M., Srivastava, A., Velayudhan, S. R. (2018). Generation of an integration-free IPSC line (CSCRI005-A) from erythroid progenitor cells of a healthy Indian male individual. Stem Cell Research, 29, 148–151. https://doi.org/10.1016/j.scr.2018.03.020.
• BaddamGSC, Sana VP , Maddali M and Ramachandra S (2018). Validity of FNAC for the Diagnosis of Leprosy. Indian J Lepr. 90 : 137-146. https://imsear.searo.who.int/handle/123456789/195005

Bio Data

Work Experience:

• Internship: M S Ramaiah Medical College, RGUHS, Bengaluru from March 2010 to March 2011
• Senior Resident: Department of Pathology, Gandhi medical college, Hyderabad from May 2015 to May 2016
• Senior Resident: Department of Haematology, Christian Medical college from October 2018 till date

Awards

• Third Prize in Poster Presentation – Molecular characterization of triple negative myeloproliferative neoplasms (TN-MPN) by targeted next generation sequencing (NGS) – ISHBT 2018, Kochi
• First prize in oral presentation – Molecular spectrum of Hemochromatosis in India – ISHBT 2017, Guwahati