Haematology News/Publications

Faculty

Innovative Young biotechnologist award for Dr Jayandharan GR.

Recent Publications - 2016

  • Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia. Cancer Chemother Pharmacol. Varatharajan S, Panetta JC, Abraham A, Karathedath S, Mohanan E, Lakshmi KM, Arthur N, Srivastava VM, Nemani S, George B, Srivastava A, Mathews V, Balasubramanian P. 2016 Oct 13. PubMed PMID: 27738808.
  • Long-term outcome following splenectomy for chronic and persistent immune thrombocytopenia (ITP) in adults and children : Splenectomy in ITP. Ahmed R, Devasia AJ, Viswabandya A, Lakshmi KM, Abraham A, Karl S, Mathai J, Jacob PM, Abraham D, Srivastava A, Mathews V, George B. Ann Hematol. 2016 Sep;95(9):1429-34. doi: 10.1007/s00277-016-2738-3. PubMed PMID: 27370992.
  • Role of endovascular embolization in treatment of acute bleeding complications in haemophilia patients. Garge S, Keshava SN, Moses V, Mammen S, Ahmed M, Chiramel GK, Cherian V, Manasseh N, George B, Mathews V, Abraham A, Viswabandya A, Srivastava A, Gibikote S. Br J Radiol. 2016 Jul 12:20151064. PubMed PMID: 27327402.
  • Surgical procedures in patients with Glanzmann's thrombasthenia: case series and literature review. Ganapule A, Jain P, Nambiar FA, Korula A, Abraham A, Mammen J, George B, Mathews V, Srivastava A, Viswabandya A. Blood CoagulFibrinolysis. 2016 Jun 6. PubMed PMID: 27273143.
  • Asia-Pacific Hematology Consortium Report on approach to multiple myeloma. Survey results from the 6th International Hematologic Malignancies Conference: Bridging the Gap 2015, Beijing, China. Lu J, Hou J, Liu KY, Parmar S, De La Fuente A, Andersson B, Yan C, Zhou D, Tan D, Ritchie D, Wu D, Shpall E, Laport GG, Li J, Hu J, Zhang LS, Wang M, Malhotra P, Jiang Q, Qin Y, Wong R, Champlin R, Issaragrisil S, Iyer S, Mathews V, Wang Y, Hu Y, Xiao Z, Shao Z, Rosengarten R, Steuernagle J 4th, Xiao JH, Orlowski R, Chim CS. Leuk Lymphoma. 2016 Jul;57(7):1534-8. doi: 10.3109/10428194.2015.1135434.PMID: 26887657
  • Identification of Stable OCT4+NANOG- State in Somatic Cell Reprogramming.Aalam SM, Manian KV, Bharathan SP, Mayuranathan T, Velayudhan SR.Cell Reprogram. 2016 Sep 13. PMID: 27622636
  • Chorionic villous sampling through transvaginal ultrasound approach: A retrospective analysis of 1138 cases. Kamath MS, Pradhan S, Edison ES, Velayudhan SR, Antonisamy B, Karthikeyan M, Mangalaraj AM, Kunjummen A, George K. J Obstet Gynaecol Res. 2016 Oct;42(10):1229-1235. doi: 10.1111/jog.13070.
  • Editorial: Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells: Ushering of a New Era in Personalized Cell Therapies. Pal R, Mariappan I, Velayudhan SR. Curr Stem Cell Res Ther. 2016;11(2):97-8. No abstract available. PMID: 26592539
  • Understanding the Molecular Basis of Heterogeneity in Induced Pluripotent Stem Cells.Manian KV, Aalam SM, Bharathan SP, Srivastava A, Velayudhan SR. Cell Reprogram. 2015 Dec;17(6):427-40. doi: 10.1089/cell.2015.0013
  • Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. Deshpande PA, Srivastava VM, Mani S, Anandhan S, Meena J, Abraham A, Viswabandya A, George B, Srivastava A, Mathews V, Balasubramanian P. Leuk Lymphoma. 2016 Oct;57(10):2481-4. doi: 10.3109/10428194.2016.1151512. PubMed PMID: 26942999.
  • Leukocyte Adhesion Deficiency-I: Clinical and Molecular Characterization in an Indian Population. Deshpande P, Kathirvel K, Alex AA, Korula A, George B, Shaji RV, Mathews V. Indian J Pediatr. 2016 Aug;83(8):799-804. doi: 10.1007/s12098-016-2051-0. PubMed PMID: 26924654.
  • De-escalation of treatment for acute promyelocytic leukaemia? Mathews V. Lancet Haematol. 2015 Sep;2(9):e348-9. doi: 10.1016/S2352-3026(15)00129-5. PubMed PMID: 26685765.
  • Treatment rates of paediatric acute myeloid leukaemia: a view from three tertiary centres in India - response to Philip C, George B, Korula A, Srivastava A, Balasubramanian P, Mathews V. Gupta et al. Br J Haematol. 2016 Oct;175(2):347-349. doi: 10.1111/bjh.13857. PubMed PMID: 26627639.
  • Clinical, Hematological and Molecular Analysis of Homozygous Hb E (HBB: c.79G > A) in the Indian Population. Hemoglobin. Jayasree D, Shaji RV, George B, Mathews V, Srivastava A, Edison ES. 2016;40(1):16-9. doi: 10.3109/03630269.2015.1086880. PubMed PMID: 26554862.

Publications - 2014-2015

  • Deshpande PA, Srivastava VM, Mani S, Anandhan S, Meena J, Abraham A, Viswabandya A, George B, Srivastava A, Mathews V, Balasubramanian P. Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. Leuk Lymphoma. 2016 Mar 4:1-4. [Epub ahead of print] PubMed PMID: 26942999.
  • Deshpande P, Kathirvel K, Alex AA, Korula A, George B, Shaji RV, Mathews V. Leukocyte Adhesion Deficiency-I: Clinical and Molecular Characterization in an Indian Population. Indian J Pediatr. 2016 Feb 29. [Epub ahead of print] PubMed PMID: 26924654.
  • Mathews V. De-escalation of treatment for acute promyelocytic leukaemia? Lancet Haematol. 2015 Sep;2(9):e348-9. doi: 10.1016/S2352-3026(15)00129-5. Epub 2015 Aug 20. PubMed PMID: 26685765.
  • Thangakunam B, Christopher DJ, Mathews V, Srivastava A. Mesenchymal stromal stem cell therapy in advanced interstitial lung disease - Anaphylaxis and short-term follow-up. Lung India. 2015 Sep-Oct;32(5):486-8. doi: 10.4103/0970-2113.164156. PubMed PMID: 26628765; PubMed Central PMCID: PMC4587005.
  • Philip C, George B, Korula A, Srivastava A, Balasubramanian P, Mathews V. Treatment rates of paediatric acute myeloid leukaemia: a view from three tertiary centres in India - response to Gupta et al. Br J Haematol. 2015 Dec 2. doi: 10.1111/bjh.13857. [Epub ahead of print] PubMed PMID: 26627639.
  • Jayasree D, Shaji RV, George B, Mathews V, Srivastava A, Edison ES. Clinical, Hematological and Molecular Analysis of Homozygous Hb E (HBB: c.79G > A) in the Indian Population. Hemoglobin. 2016;40(1):16-9. doi: 10.3109/03630269.2015.1086880. Epub 2015 Nov 11. PubMed PMID: 26554862.
  • Abraham A, Varatharajan S, Karathedath S, Philip C, Lakshmi KM, Jayavelu AK, Mohanan E, Janet NB, Srivastava VM, Shaji RV, Zhang W, Abraham A, Viswabandya A George B, Chandy M, Srivastava A, Mathews V, Balasubramanian P. RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia. Pharmacogenomics. 2015 Jul;16(8):877-90. doi: 10.2217/pgs.15.44. Epub 2015 Jun 17. PubMed PMID: 26083014.
  • Philip C, George B, Ganapule A, Korula A, Jain P, Alex AA, Lakshmi KM, Sitaram U, Abubacker FN, Abraham A, Viswabandya A, Srivastava VM, Srivastava A, Balasubramanian P, Mathews V. Acute myeloid leukaemia: challenges and real world data from India. Br J Haematol. 2015 Jul;170(1):110-7. doi: 10.1111/bjh.13406. Epub 2015 Apr 9. PubMed PMID: 25858293.
  • Chendamarai E, Ganesan S, Alex AA, Kamath V, Nair SC, Nellickal AJ, Janet NB, Srivastava V, Lakshmi KM, Viswabandya A, Abraham A, Aiyaz M, Mullapudi N, Mugasimangalam R, Padua RA, Chomienne C, Chandy M, Srivastava A, George B, Balasubramanian P, Mathews V. Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance. PLoS One. 2015 Mar 30;10(3):e0121912. doi: 10.1371/journal.pone.0121912. eCollection 2015. PubMed PMID: 25822503; PubMed Central PMCID: PMC4378855.
  • Abraham A, George B, Ahmed R, Viswabandya A, Mathews V, Lakshmi KM, et al. Outcome of treatment with a low cost protocol in adults with T cell acute lymphoblastic leukemia in a tertiary care center in India. Leuk Lymphoma 2014;55(4):947-9.
  • Abraham A, Devasia AJ, Varatharajan S, Karathedath S, Balasubramanian P, Mathews V. Effect of cytosine arabinoside metabolizing enzyme expression on drug toxicity in acute myeloid leukemia. Ann Hematol 2014.
  • Abraham A, Karathedath S, Kumaraswamy V, Jayavelu AK, Mani S, Srivastava VM, et al. Novel NPM1 mutation in the 3'-untranslated region identified in two patients with acute myeloid leukemia. Leuk Lymphoma 2014;55(6):1421-4.
  • Abraham A, Karathedath S, Varatharajan S, Markose P, Chendamarai E, Jayavelu AK, et al. ABCB6 RNA expression in leukemias--expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia. Ann Hematol 2014;93(3):509-12.
  • Athiyarath R, George B, Mathews V, Srivastava A, Edison ES. Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in beta-thalassemia. Ann Hematol 2014;93(12):2093-5.
  • Mathews V, Srivastava A, Chandy M. Allogeneic stem cell transplantation for thalassemia major. Hematol Oncol Clin North Am 2014;28(6):1187-200.
  • Mayuranathan T, Rayabaram J, Das R, Arora N, Edison ES, Chandy M, et al. Identification of rare and novel deletions that cause (deltabeta)0-thalassaemia and hereditary persistence of foetal haemoglobin in Indian population. Eur J Haematol 2014;92(6):514-20.
  • Arora N, Nair S, Pai R, Ahmed R, Abraham A, Viswabandya A, et al. V-raf murine sarcoma viral oncogene homolog B (BRAF) mutations in hairy cell leukaemia. Indian J Pathol Microbiol 2015;58(1):62-5.
  • Allogeneic Stem Cell Transplantation forThalassemia Major. Hematol Oncol Clin North Am. 2014 Dec;28(6):1187-1200. doi:10.1016/j.hoc.2014.08.009. Mathews V, Srivastava A, Chandy M. Epub 2014 Sep 22. Review. PubMed PMID: 25459187.
  • Effect of cytosine arabinoside metabolizing enzyme expression on drug toxicity in acute myeloid leukemia. Abraham A, Devasia AJ, Varatharajan S, Karathedath S, Balasubramanian P,Mathews V. Ann Hematol. 2014 Nov 13. [Epub ahead of print] PubMed PMID: 25391240.
  • Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in ß-thalassemia. Athiyarath R, George B, Mathews V, Srivastava A, Edison ES. Ann Hematol. 2014 Dec;93(12):2093-5. doi: 10.1007/s00277-014-2113-1. Epub 2014 May 28. PubMed PMID: 24867648.
  • Mathews V. Generic imatinib: the real-deal or just a deal? Leuk Lymphoma. 2014 Dec;55(12):2678-80. doi: 10.3109/10428194.2014.921299. PubMed PMID:24798742.
  • Sen D, Balakrishnan B, Jayandharan GR. Cellular unfolded protein response against viruses used in gene therapy. Front Microbiol 2014; in press
  • Selot R, Hareendran S, Jayandharan GR. Developing immunologically inert adeno-associated virus (AAV) vectors for gene therapy: possibilities and limitations. Curr Pharm Biotechnol 2014; in press.
  • Balakrishnan B, Jayandharan GR. Basic biology of Adeno-associated virus (AAV) vectors used in gene therapy. Curr Gene Ther 2014; in press.
  • Ramesh B. Batchu, Oksana V. Gruzdyna, Amberly M. Moreno-Bost, Susann Szmania, Jayandharan GR, Arun Srivastava, Bala K. Kolli, Donald W. Weaver, Frits van Rhee, Scott A. Gruber. Efficient lysis of epithelial ovarian cancer cells by MAGE-A3-induced cytotoxic T lymphocytes using rAAV-6 capsid mutant vector. Vaccine 6 January 2014 [Epub ahead of print].
  • Hareendran S, Balakrishnan B, Sen D, Kumar S, Srivastava A, Jayandharan GR. Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them. Rev Med Virol. 2013 Sep 10. doi: 10.1002/rmv.1762. [Epub ahead of print] PubMed PMID: 24023004.
  • Athiyarath R, Arora N, Fuster F, Schwarzenbacher R, Ahmed R, George B, Chandy M, Srivastava A, Rojas AM, Sanchez M, Edison ES. Two novel missense mutations in iron transport protein transferrin causing hypochromic microcytic anaemia and haemosiderosis: molecular characterization and structural implications. Br J Haematol. 2013 Jul 24. doi: 10.1111/bjh.12487. [Epub ahead of print] PubMed PMID: 23888904.
  • Abraham A, Karathedath S, Varatharajan S, Markose P, Chendamarai E, Jayavelu AK, George B, Srivastava A, Mathews V, Balasubramanian P. ABCB6 RNA expression in leukemias-expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia. Ann Hematol. 2013 Jun 22. [Epub ahead of print] PubMed PMID: 23793916.
  • Desire S, Mohanan EP, George B, Mathews V, Chandy M, Srivastava A, Balasubramanian P. A rapid & sensitive liquid chromatography- tandem mass spectrometry method for the quantitation of busulfan levels in plasma & application for routine therapeutic monitoring in haematopoietic stem cell transplantation. Indian J Med Res. 2013 Apr;137(4):777-84. PubMed PMID: 23703347; PubMed Central PMCID: PMC3724260.
  • Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, Srivastava A, Jayandharan GR. Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. Sci Rep. 2013;3:1832. doi: 10.1038/srep01832. PubMed PMID: 23665951; PubMed Central PMCID: PMC3652085.
  • Mathews V, George B, Viswabandya A, Abraham A, Ahmed R, Ganapule A, Sindhuvi E, Lakshmi KM, Srivastava A. Improved clinical outcomes of high risk β Thalassemia major patients undergoing a HLA matched related allogeneic stem cell transplant with a treosulfan based conditioning regimen and peripheral blood stem cell grafts. PLoS One. 2013 Apr 26;8(4):e61637. doi: 10.1371/journal.pone.0061637. Print 2013. PubMed PMID: 23637873; PubMed Central PMCID: PMC3637210.
  • Sen D, Gadkari RA, Sudha G, Gabriel N, Kumar YS, Selot R, Samuel R, Rajalingam S, Ramya V, Nair SC, Srinivasan N, Srivastava A, Jayandharan GR. Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):104-16. doi: 10.1089/hgtb.2012.195. PubMed PMID: 23442071.
  • Gabriel N, Hareendran S, Sen D, Gadkari RA, Sudha G, Selot R, Hussain M, Dhaksnamoorthy R, Samuel R, Srinivasan N, Srivastava A, Jayandharan GR. Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):80-93. doi: 10.1089/hgtb.2012.194. Epub 2013 Mar 15. PubMed PMID: 23379478.
  • Balakrishnan B, Sen D, Hareendran S, Roshini V, David S, Srivastava A, Jayandharan GR. Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS One. 2013;8(1):e53845. doi: 10.1371/journal.pone.0053845. Epub 2013 Jan 8. PubMed PMID: 23320106; PubMed Central PMCID: PMC3540029.
  • Jain PP, Parihar M, Ahmed R, Abraham A, Vishwabandya A, George B, Mathews V, Srivastava A, Srivastava VM. Fluorescence in situ hybridization patterns of BCR/ABL1 fusion in chronic myelogenous leukemia at diagnosis. Indian J Pathol Microbiol. 2012 Jul-Sep;55(3):347-51. doi: 10.4103/0377-4929.101742. PubMed PMID: 23032829.
  • Varatharajan S, Abraham A, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P. Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia. Eur J Clin Pharmacol. 2012 Dec;68(12):1577-86. doi: 10.1007/s00228-012-1291-9. Epub 2012 May 5. PubMed PMID: 22562609.
  • Sabapathy V, Ravi S, Srivastava V, Srivastava A, Kumar S. Long-term cultured human term placenta-derived mesenchymal stem cells of maternal origin displays plasticity. Stem Cells Int. 2012;2012:174328. doi: 10.1155/2012/174328. Epub 2012 Mar 26. PubMed PMID: 22550499; PubMed Central PMCID: PMC3329664.
  • Patkar N, Alex AA, B B, Ahmed R, Abraham A, George B, Vishwabandya A, Srivastava A, Mathews V. Standardizing minimal residual disease by flow cytometry for precursor B lineage acute lymphoblastic leukemia in a developing country. Cytometry B Clin Cytom. 2012 Jul;82(4):252-8. doi: 10.1002/cyto.b.21017. Epub 2012 Mar 29. PubMed PMID: 22467604.
  • Chendamarai E, Balasubramanian P, George B, Viswabandya A, Abraham A, Ahmed R, Alex AA, Ganesan S, Lakshmi KM, Sitaram U, Nair SC, Chandy M, Janet NB, Srivastava VM, Srivastava A, Mathews V. Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Blood. 2012 Apr 12;119(15):3413-9. doi: 10.1182/blood-2011-11-393264. Epub 2012 Feb 28. PubMed PMID: 22374701.

Publications

2013

  • Jain R, T L, Chandran J, Jayandharan GR, Palle A, Moses PD. A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans. Blood Coagul Fibrinolysis. 2013; 24:890-2
  • Devi GS, Arora N, Rajkumar SV, Edison ES, Srivastava A, Jayandharan GR*. Fluorescent PCR-based gene dose analysis for detection of deletion mutations in carriers of haemophilia. Haemophilia. 2013 Jul 16. doi: 10.1111/hae.12233.
  • Sangeetha H, Balakrishnan B, Sen D, Kumar S, Srivastava A, Jayandharan GR*. Adeno-associated virus (AAV) vectors in gene therapy: Immune challenges and strategies to circumvent them. Rev Med Virol; 2013, in press.
  • Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, Srivastava A, Jayandharan GR. Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. Sci Rep; 2013, 3: 1832. DOI: 10.1038/srep01832.
  • Song L, Kauss MA, Kopin E, Chandra M, Ul-Hasan T, Miller E, Jayandharan GR,Rivers AE, Aslanidi GV, Ling C, Li B, Ma W, Li X, Andino LA, Zhong L, Tarantal AF, Yoder MC, Wong KK, Jr, Tan M, Chatterjee S, Srivastava A. Optimizing the transduction efficiency of human hematopoietic stem cells using capsid-modified AAV6 vectors in vitro and in a xenograft mouse model in vivo. Cytotherapy 2013, in press.
  • Sumitha E, Jayandharan GR, Neeraj A, David S, Sankari Devi G, ShenbagaPriya P, Nair SC, George B, Viswabandya A, Mathews V, Chandy M, Srivastava A. Molecular basis of fibrinogen deficiency in 25 patients from India. Haemophilia2013, in press.
  • Sen D, Gadkari RA, Sudha G, Gabriel N, Sathish Kumar Y, Selot R, Samuel R, Rajalingam S, Ramya V, Nair SC,Srinivasan N, Srivastava A, Jayandharan GR. Targeted modifications in adeno-associated virus (AAV) serotype -8 capsid improves its hepatic gene transfer efficiency in vivo. Hum Gene Ther Methods 2013; in press.
  • Gabriel N, Hareendran S, Sen D, Gadkari RA, Govindarajan S, Hussain M, Duraiswamy R, Samuel R, Srinivasan N, Srivastava A, Jayandharan GR. Bio-Engineering of Adeno-Associated Virus Serotype (AAV)-2 Capsid at Serine/Threonine/Lysine Residues Improves Its Transduction Efficiency Both In Vitro and In Vivo. Hum Gene Ther Methods 2013; in press.
  • Balakrishnan B, Sen D, David S, Srivastava A, Srivastava A, Jayandharan GR. Activation of the Cellular Unfolded Protein Response by Recombinant Adeno-Associated Virus Vectors. PLoS ONE 2013; 8(1): e53845. doi:10.1371/journal.pone.0053845.
  • Sen D, Chapla A, Walter N, Daniel V, Srivastava A, Jayandharan GR. Nuclear Factor (NF)-κB is a major regulator of blood induced joint damage in a murine model of hemophilia. J Thromb Haemost 2013, 11: 293-306.
  • Song L, Li X, Jayandharan GR, Wang Y, Aslanidi GV, Ling C, Zhong L, Gao G, Yoder MC, Ling C, Tan M, Srivastava A. High-efficiency transduction of primary human hematopoietic stem cells and erythroid lineage-restricted expression by optimized AAV6 serotype vectors in vitro and in a murine xenograft model in vivo. PLoS ONE 2013; in press.

2012