Faculty

Dr. Biju George

Dr. Biju George MBBS, MD, DM

Professor

Areas of interest include aplastic anemia, myelodysplastic syndromes, stem cell transplantation, graft versus host disease, ITP, infections and immunotherapy

S.No Study title Principal Investigator
1. A Phase 3, Randomized, Double-blind study of PF-05280586 Versus Rituximab for the First-line Treatment of Patients with CD20-Positive, Low Tumor Burden, Follicular Lymphoma (Protocol Number: B3281006) – Pfizer Dr. Biju George
2. A two-part study: Interventional phase II single-arm trial to assess efficacy and safety of Eltrombopag combined with cyclosporine as first line therapy in patients with severe acquired aplastic anemia, and an extension with up to 60- month follow-up Dr. Biju George
INVESTIGATOR INITIATED STUDIES
1. Phase II trial to study if the addition of fludarabine to the standard regimen of Anti-thymocyte globulin (ATG) and cyclosporine will improve remission rates in patients with severe and very severe aplastic anemia (SAA/VSAA) Dr. Biju George
2. A study of the kinetics of CMV viremia in patients undergoing bone marrow transplantation and identification of cutoffs for initiation of ganciclovir therapy in patients who show reactivation of CMV infection Dr. Biju George
3. Phase II trial to study if the addition of meloxicam to the standard regimen of mobilization with Colony stimulating factor (G-CSF) will improve mobilization rates in patients undergoing mobilization for autologous stem cell transplantation. Dr. Biju George
4. Multicentre Indian Study on Fungal Infections during chemotherapy (MISFIC) Dr. Biju George
5. Relevance of telomere biology in the pathogenesis and treatment outcome of patients with bone marrow failure disorders. Dr. Biju George
6. A Pilot study of Leflunomide to prevent Cytomegalovirus (CMV) reactivation in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) Dr. Biju George
  • Ram M, Ramakant P, Parmar H, George B, Paul MJ. Primary Breast T Cell Lymphoma Involving Nipple-Areolar Complex in a Young Patient. Indian J Surg. 2016 Dec;78(6):499-501. doi: 10.1007/s12262-016-1442-9. PubMed PMID: 28100950.
  • Mahabal G, George L, Bindra M, George B. Late-onset acute graft-versus-host disease mimicking hand, foot, and mouth disease. Indian Dermatol Online J. 2016 Nov-Dec;7(6):509-511. PubMed PMID: 27990387; PubMed Central PMCID: PMC5134166.
  • Pragasam AK, Yesurajan F, Doss C GP, George B, Devanga Ragupathi NK, Walia K, Veeraraghavan B. Draft Genome Sequence of Extremely Drug-Resistant Pseudomonas aeruginosa (ST357) Strain CMC_VB_PA_B22862 Isolated from a Community-Acquired Bloodstream Infection. Genome Announc. 2016 Oct 20;4(5). pii: e01092-16. doi: 10.1128/genomeA.01092-16. PubMed PMID: 27795257; PubMed Central PMCID: PMC5073252.
  • Varatharajan S, Panetta JC, Abraham A, Karathedath S, Mohanan E, Lakshmi KM, Arthur N, Srivastava VM, Nemani S, George B, Srivastava A, Mathews V, Balasubramanian P. Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia. Cancer Chemother Pharmacol. 2016 Nov;78(5):1051-1058. PubMed PMID: 27738808.
  • George A, Peter D, Pulimood S, Manipadam MT, George B, Paul MJ, Thomas JK. Rapidly progressing necrotic ulcerations and sinuses in specific cutaneous Hodgkin's disease. Indian Dermatol Online J. 2016 Sep-Oct;7(5):436-438. PubMed PMID: 27730051; PubMed Central PMCID: PMC5038116.
  • Ahmed R, Devasia AJ, Viswabandya A, Lakshmi KM, Abraham A, Karl S, Mathai J, Jacob PM, Abraham D, Srivastava A, Mathews V, George B. Long-term outcome following splenectomy for chronic and persistent immune thrombocytopenia (ITP) in adults and children : Splenectomy in ITP. Ann Hematol. 2016 Sep;95(9):1429-34. doi: 10.1007/s00277-016-2738-3. PubMed PMID: 27370992.
  • Ballen K, Woo Ahn K, Chen M, Abdel-Azim H, Ahmed I, Aljurf M, Antin J, Bhatt AS, Boeckh M, Chen G, Dandoy C, George B, Laughlin MJ, Lazarus HM, MacMillan ML, Margolis DA, Marks DI, Norkin M, Rosenthal J, Saad A, Savani B, Schouten HC, Storek J, Szabolcs P, Ustun C, Verneris MR, Waller EK, Weisdorf DJ, Williams KM, Wingard JR, Wirk B, Wolfs T, Young JA, Auletta J, Komanduri KV, Lindemans C, Riches ML. Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 Sep;22(9):1636-45. doi: 10.1016/j.bbmt.2016.06.012. PubMed PMID: 27343716; PubMed Central PMCID: PMC5008458.
  • Garge S, Keshava SN, Moses V, Mammen S, Ahmed M, Chiramel GK, Cherian V, Manasseh N, George B, Mathews V, Abraham A, Viswabandya A, Srivastava A, Gibikote S. Role of endovascular embolization in treatment of acute bleeding complications in haemophilia patients. Br J Radiol. 2016 Jul 12:20151064. [Epub ahead of print] PubMed PMID: 27327402; PubMed Central PMCID: PMC5124877.
  • Ganapule A, Jain P, Nambiar FA, Korula A, Abraham A, Mammen J, George B, Mathews V, Srivastava A, Viswabandya A. Surgical procedures in patients with Glanzmann's thrombasthenia: case series and literature review. Blood Coagul Fibrinolysis. 2016 Jun 6. [Epub ahead of print] PubMed PMID: 27273143.
  • Devasia AJ, Irodi A, George B. Broncho-Pericardial Fistula Leading to Pneumopericardium Following Allogeneic Stem Cell Transplantation. Indian J Pediatr. 2016 Oct;83(10):1206-7. doi: 10.1007/s12098-016-2117-z. PubMed PMID: 27130507.
  • Gnanasekaran KK, Chacko MP, Manipadam MT, Bindra MS, George B, Srivastava VM. Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity. Indian J Pathol Microbiol. 2016 Jan-Mar;59(1):104-6. doi: 10.4103/0377-4929.174829. PubMed PMID: 26960652.
  • Deshpande PA, Srivastava VM, Mani S, Anandhan S, Meena J, Abraham A, Viswabandya A, George B, Srivastava A, Mathews V, Balasubramanian P. Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. Leuk Lymphoma. 2016 Oct;57(10):2481-4. doi: 10.3109/10428194.2016.1151512. PubMed PMID: 26942999.
  • Deshpande P, Kathirvel K, Alex AA, Korula A, George B, Shaji RV, Mathews V. Leukocyte Adhesion Deficiency-I: Clinical and Molecular Characterization in an Indian Population. Indian J Pediatr. 2016 Aug;83(8):799-804. doi: 10.1007/s12098-016-2051-0. PubMed PMID: 26924654.
  • Kumar R, Kimura F, Ahn KW, Hu ZH, Kuwatsuka Y, Klein JP, Pasquini M, Miyamura K, Kato K, Yoshimi A, Inamoto Y, Ichinohe T, Wood WA Jr, Wirk B, Seftel M, Rowlings P, Marks DI, Schultz KR, Gupta V, Dedeken L, George B, Cahn JY, Szer J, Lee JW, Ho AY, Fasth A, Hahn T, Khera N, Dalal J, Bonfim C, Aljurf M, Atsuta Y, Saber W. Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions. Biol Blood Marrow Transplant. 2016 May;22(5):932-40. doi: 10.1016/j.bbmt.2016.01.012. PubMed PMID: 26797402; PubMed Central PMCID: PMC4826285.
  • Philip C, George B, Korula A, Srivastava A, Balasubramanian P, Mathews V. Treatment rates of paediatric acute myeloid leukaemia: a view from three tertiary centres in India - response to Gupta et al. Br J Haematol. 2016 Oct;175(2):347-349. doi: 10.1111/bjh.13857. PubMed PMID: 26627639.
  • Jayasree D, Shaji RV, George B, Mathews V, Srivastava A, Edison ES. Clinical, Hematological and Molecular Analysis of Homozygous Hb E (HBB: c.79G?>?A) in the Indian Population. Hemoglobin. 2016;40(1):16-9. doi: 10.3109/03630269.2015.1086880. PubMed PMID: 26554862.
  • Deshpande P, Kamalanathan N, Sampath E, George B,Shaji RV, Edison ES. Characterization of Clinical and Laboratory Profiles of the Deletional ?2-Globin Gene Polyadenylation Signal Sequence (AATAAA?>?AATA-?-) in an Indian Population. Hemoglobin. 2015;39(6):415-8. doi: 10.3109/03630269.2015.1079785. PubMed PMID: 26365411.
  • Pasquini MC, Zhang MJ, Medeiros BC, Armand P, Hu ZH, Nishihori T, Aljurf MD, Akpek G, Cahn JY, Cairo MS, Cerny J, Copelan EA, Deol A, Freytes CO, Gale RP, Ganguly S, George B, Gupta V, Hale GA, Kamble RT, Klumpp TR, Lazarus HM, Luger SM, Liesveld JL, Litzow MR, Marks DI, Martino R, Norkin M, Olsson RF, Oran B, Pawarode A, Pulsipher MA, Ramanathan M, Reshef R, Saad AA, Saber W, Savani BN, Schouten HC, Ringdén O, Tallman MS, Uy GL, Wood WA Jr, Wirk B, Pérez WS, Batiwalla M, Weisdorf DJ. Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies. Biol Blood Marrow Transplant. 2016 Feb;22(2):248-57. doi: 10.1016/j.bbmt.2015.08.024. PubMed PMID: 26327629; PubMed Central PMCID: PMC4716890.
  • Abraham A, Varatharajan S, Karathedath S, Philip C, Lakshmi KM, Jayavelu AK, Mohanan E, Janet NB, Srivastava VM, Shaji RV, Zhang W, Abraham A, Viswabandya A, George B,Chandy M, Srivastava A, Mathews V, Balasubramanian P. RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia. Pharmacogenomics. 2015 Jul;16(8):877-90. doi: 10.2217/pgs.15.44. PubMed PMID: 26083014.
  • Athiyarath R, Shaktivel K, Abraham V, Singh D, Bondu JD, Chapla A, George B, Srivastava A, Edison ES. Association of genetic variants with response to iron supplements in pregnancy. Genes Nutr. 2015 Jul;10(4):474. doi: 10.1007/s12263-015-0474-2. PubMed PMID: 26024779; PubMed Central PMCID: PMC4449341.
  • Philip C, George B, Ganapule A, Korula A, Jain P, Alex AA, Lakshmi KM, Sitaram U, Abubacker FN, Abraham A, Viswabandya A, Srivastava VM, Srivastava A, Balasubramanian P, Mathews V. Acute myeloid leukaemia: challenges and real world data from India. Br J Haematol. 2015 Jul;170(1):110-7. doi: 10.1111/bjh.13406. PubMed PMID: 25858293; PubMed Central PMCID: PMC4864448.
  • Chendamarai E, Ganesan S, Alex AA, Kamath V, Nair SC, Nellickal AJ, Janet NB, Srivastava V, Lakshmi KM, Viswabandya A, Abraham A, Aiyaz M, Mullapudi N, Mugasimangalam R, Padua RA, Chomienne C, Chandy M, Srivastava A, George B, Balasubramanian P, Mathews V. Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance. PLoS One. 2015 Mar 30;10(3):e0121912. doi: 10.1371/journal.pone.0121912. PubMed PMID: 25822503; PubMed Central PMCID: PMC4378855.
  • Arora N, Nair S, Pai R, Nair S, Ahmed R, Abraham A, Viswabandya A, George B, Balasubramanian P, Srivastava A, Mathews V. V-raf murine sarcoma viral oncogene homolog B (BRAF) mutations in hairy cell leukaemia. Indian J Pathol Microbiol. 2015 Jan-Mar;58(1):62-5. doi: 10.4103/0377-4929.151190. PubMed PMID: 25673595.
  • Athiyarath R, George B, Abraham A, Viswabandya A, Srivastava A, Edison ES. Genetic modifiers of secondary iron overload in beta thalassemia major. Blood Cells Mol Dis. 2015 Mar;54(3):242-3. doi: 10.1016/j.bcmd.2014.12.006. PubMed PMID: 25601433.
  • Senapati J, Devasia AJ, Alex AA, George B. Early T cell precursor lymphoid blast crisis of chronic myeloid leukemia - a novel transformation. Hematol Oncol Stem Cell Ther. 2015 Mar;8(1):43-6. doi: 10.1016/j.hemonc.2014.11.002. PubMed PMID: 25497977.
  • Senapati J, Devasia AJ, David S, Manipadam MT, Nair S, Jayandharan GR, George B. Diffuse large B cell lymphoma in wiskott-Aldrich syndrome: a case report and review of literature. Indian J Hematol Blood Transfus. 2014 Sep;30(Suppl 1):309-13. doi: 10.1007/s12288-014-0377-1. PubMed PMID: 25332606; PubMed Central PMCID: PMC4192205.
  • Athiyarath R, George B, Mathews V, Srivastava A, Edison ES. Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in ?-thalassemia. Ann Hematol. 2014 Dec;93(12):2093-5. doi: 10.1007/s00277-014-2113-1. PubMed PMID: 24867648.
  • Saheer S, Thangakunam B, Christopher DJ, George B. Lenalidomide-induced diffuse alveolar hemorrhage. Lung India. 2014 Jan;31(1):90-1. doi: 10.4103/0970-2113.126004. PubMed PMID: 24669097; PubMed Central PMCID: PMC3960826.
  • George B, Mathews V, Lakshmi KM, Melinkeri S, Sharma A, Viswabandya A, Sharma S, Das S, Ahmed R, Abraham A, Nair V, Apte S, Chandy M, Srivastava A. The use of a fludarabine-based conditioning regimen in patients with severe aplastic anemia--a retrospective analysis from three Indian centers. Clin Transplant. 2013 Nov-Dec;27(6):923-9. doi: 10.1111/ctr.12263. PubMed PMID: 24304374.
  • Warlick ED, Paulson K, Brazauskas R, Zhong X, Miller AM, Camitta BM, George B, Savani BN, Ustun C, Marks DI, Waller EK, Baron F, Freytes CO, Socie G, Akpek G, Schouten HC, Lazarus HM, Horwitz EM, Koreth J, Cahn JY, Bornhauser M, Seftel M, Cairo MS, Laughlin MJ, Sabloff M, Ringdén O, Gale RP, Kamble RT, Vij R, Gergis U, Mathews V, Saber W, Chen YB, Liesveld JL, Cutler CS, Ghobadi A, Uy GL, Eapen M, Weisdorf DJ, Litzow MR. Effect of postremission therapy before reduced-intensity conditioning allogeneic transplantation for acute myeloid leukemia in first complete remission. Biol Blood Marrow Transplant. 2014 Feb;20(2):202-8. doi: 10.1016/j.bbmt.2013.10.023. PubMed PMID: 24184335; PubMed Central PMCID: PMC3924751.
  • Athiyarath R, Arora N, Fuster F, Schwarzenbacher R, Ahmed R, George B, Chandy M, Srivastava A, Rojas AM, Sanchez M, Edison ES. Two novel missense mutations in iron transport protein transferrin causing hypochromic microcytic anaemia and haemosiderosis: molecular characterization and structural implications. Br J Haematol. 2013 Nov;163(3):404-7. doi: 10.1111/bjh.12487. PubMed PMID: 23888904.
  • Abraham A, Karathedath S, Varatharajan S, Markose P, Chendamarai E, Jayavelu AK, George B, Srivastava A, Mathews V, Balasubramanian P. ABCB6 RNA expression in leukemias--expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia. Ann Hematol. 2014 Mar;93(3):509-12. doi: 10.1007/s00277-013-1821-2. PubMed PMID: 23793916.
  • Desire S, Mohanan EP, George B, Mathews V, Chandy M, Srivastava A, Balasubramanian P. A rapid & sensitive liquid chromatography- tandem mass spectrometry method for the quantitation of busulfan levels in plasma & application for routine therapeutic monitoring in haematopoietic stem cell transplantation. Indian J Med Res. 2013 Apr;137(4):777-84. PubMed PMID: 23703347; PubMed Central PMCID: PMC3724260.
  • Mathews V, George B, Viswabandya A, Abraham A, Ahmed R, Ganapule A, Sindhuvi E, Lakshmi KM, Srivastava A. Improved clinical outcomes of high risk ? thalassemia major patients undergoing a HLA matched related allogeneic stem cell transplant with a treosulfan based conditioning regimen and peripheral blood stem cell grafts. PLoS One. 2013 Apr 26;8(4):e61637. doi: 10.1371/journal.pone.0061637. PubMed PMID: 23637873; PubMed Central PMCID: PMC3637210.
  • Simon EG, Chacko A, Dutta AK, Joseph AJ, George B. Acute nonvariceal upper gastrointestinal bleeding--experience of a tertiary care center in southern India. Indian J Gastroenterol. 2013 Jul;32(4):236-41. doi: 10.1007/s12664-013-0305-6. PubMed PMID: 23526425.
  • Jain PP, Parihar M, Ahmed R, Abraham A, Vishwabandya A, George B, Mathews V, Srivastava A, Srivastava VM. Fluorescence in situ hybridization patterns of BCR/ABL1 fusion in chronic myelogenous leukemia at diagnosis. Indian J Pathol Microbiol. 2012 Jul-Sep;55(3):347-51. doi: 10.4103/0377-4929.101742. PubMed PMID: 23032829.
  • Varatharajan S, Abraham A, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P. Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia. Eur J Clin Pharmacol. 2012 Dec;68(12):1577-86. doi: 10.1007/s00228-012-1291-9. PubMed PMID: 22562609.
  • Patkar N, Alex AA, B B, Ahmed R, Abraham A, George B, Vishwabandya A, Srivastava A, Mathews V. Standardizing minimal residual disease by flow cytometry for precursor B lineage acute lymphoblastic leukemia in a developing country. Cytometry B Clin Cytom. 2012 Jul;82(4):252-8. doi: 10.1002/cyto.b.21017. PubMed PMID: 22467604.
  • Chendamarai E, Balasubramanian P, George B, Viswabandya A, Abraham A, Ahmed R, Alex AA, Ganesan S, Lakshmi KM, Sitaram U, Nair SC, Chandy M, Janet NB, Srivastava VM, Srivastava A, Mathews V. Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Blood. 2012 Apr 12;119(15):3413-9. doi: 10.1182/blood-2011-11-393264. PubMed PMID: 22374701.
  • Abraham A, Varatharajan S, Abbas S, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P. Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia. Pharmacogenomics. 2012 Feb;13(3):269-82. doi: 10.2217/pgs.11.149. PubMed PMID: 22304580.
  • Sellathamby S, Lakshmi KM, Busson M, Viswabandya A, George B, Mathews V, Chandy M, Charron D, Krishnamoorthy R, Tamouza R, Srivastava A. Polymorphisms in the immunoregulatory genes are associated with hematopoietic recovery and increased susceptibility to bacterial infections in patients with thalassaemia major undergoing matched related hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2012 Aug;18(8):1219-26. doi: 10.1016/j.bbmt.2012.01.011. PubMed PMID: 22252124.
  • Balasubramanian P, Chendamarai E, Markose P, Fletcher L, Branford S, George B, Mathews V, Chandy M, Srivastava A. International reporting scale of BCR-ABL1 fusion transcript in chronic myeloid leukemia: first report from India. Acta Haematol. 2012;127(3):135-42. doi: 10.1159/000334716. PubMed PMID: 22249155.
  • Edison ES, Venkatesan RS, Govindanattar SD, George B, Shaji RV. A novel 26 bp deletion [HBB: c.20_45del26bp] in exon 1 of the ?-globin gene causing ?-thalassemia major. Hemoglobin. 2012;36(1):98-102. doi: 10.3109/03630269.2011.641135. PubMed PMID: 22233277.
  • Mathews V, Chendamarai E, George B, Viswabandya A, Srivastava A. Treatment of acute promyelocytic leukemia with single-agent arsenic trioxide. Mediterr J Hematol Infect Dis. 2011;3(1):e2011056. doi: 10.4084/MJHID.2011.056. PubMed PMID: 22220253; PubMed Central PMCID: PMC3248333.
  • Patkar N, Nair S, Alex AA, Parihar M, Manipadam MT, Arora N, Ahmed R, Abraham A, George B, Viswabandya A, Srivastava V, Srivastava A, Mathews V. Clinicopathological features of hepatosplenic T cell lymphoma: a single centre experience from India. Leuk Lymphoma. 2012 Apr;53(4):609-15. doi: 10.3109/10428194.2011.622421. PubMed PMID: 21916832.
  • Parihar M, Kumar JA, Sitaram U, Balasubramanian P, Abraham A, Viswabandya A, George B, Mathews V, Srivastava A, Srivastava VM. Cytogenetic analysis of acute myeloid leukemia with t(8;21) from a tertiary care center in India with correlation between clinicopathologic characteristics and molecular analysis. Leuk Lymphoma. 2012 Jan;53(1):103-9. doi: 10.3109/10428194.2011.603447. PubMed PMID: 21745004.

For complete list of publications, please visit - https://www.ncbi.nlm.nih.gov/pubmed/?term=biju+george+vellore

Will be update Soon