Faculty

Dr. Alok Srivastava

Dr. Alok Srivastava MD, FRACP, FRCPA, FRCP

Professor Membership
Will be update Soon
S.No Study title Principal Investigator
1. Study of Inspiration’s Recombinant Factor IX Product, IB1001, in Previously Treated Pediatric Subjects with Hemophilia B – Cangene International Dr. Alok Srivastava
2. Pharmacokinetic study of Treosulfan in patients eligible for treosulfan based conditioning regimen prior to HSCT (Hematopoietic stem cell transplantation) – Emcure Dr. Alok Srivastava
INVESTIGATOR INITIATED STUDIES
1. Assessment of the effectiveness of prophylactic replacement of lower than ‘standard’ doses of clotting factor concentrates in children with severe hemophilia A (BAYER AWARDS) Dr. Alok Srivastava
No. Project Title Duration
(Year)
Funding Agency Starting Date

Current Projects

1 Low dose prophylaxis in hemophilia – A multicenter international study in Developing countries 3 Bayer Hemophilia Awards Program, USA 2012
2 Assessment of an Anti-TFPI Aptamer in correcting the abnormal haemostasis of blood from patients with haemophilia and evaluation of its concentration - effect relationship. [Principal Investigator] 1 Archemix Corporation, USA 2010
3 Program support for Molecular Haematology – 7 projects Govt. of India [Co-Team Leader] 5 Department of Biotechnology,
Govt. of India
2009
4 Novel Molecular Mechanisms leading to a haemophilia “A” phenotype 2 Bayer Health Care-Hemophilia Awards Program, USA 2009
5 Centre for Stem Cell Research-A CMC – DBT Collaboration
[Project Coordinator]
5 Department of Biotechnology
Govt. of India
2006

Completed Projects

1 An open label, single arm study to evaluate the efficacy and safety of
Rituximab in CD 20+ve Diffuse large
B cell lymphoma along with CHOP
Chemotherapy [Principal Investigator]
4 Dr. Reddy’s Laboratory 2006
2 Musculo-skeletal function in hemophilia in developing countries – First international multi-center study [Principal Investigator] 5 Bayer Health Care,
Hemophilia Awards Program, USA
2003
3 Evaluation of adult stem cells (Haematopoietic, Mesenchymal, Gastrointestinal epithelial):
Biology and potential applications In tissue regeneration, immune-modulation and as vehicles for gene therapy. [Program Coordinator]
3 Department of Biotechnology
Govt. of India
2005
4 Haematopoietic stem cells: Establishing technology for collection, isolation, purification and expansion. [Principal Investigator] 3 Department of Biotechnology,
Govt. of India
2002
5 Role of minor HLA and other immunogenetic markers in familial bone marrow transplantation for thalassaemia major. [Principal Investigator-India] 2 ICMR-INSERM
Govts. of India and France
6 Pharmacogenetics of Busulfan and Cyclophophamide [Principal Investigator] 3 CEFIPRA
(Indo-French)
2001
7 Establishing a centre for genetic diagnosis of haemat. diseases (thalassaemia, haem-mophilia, Glanzmann thrombasthenia, leukaemias) [Joint Investigator] 6 Department of Biotechnology,
Govt. of India
1999
8 Joint study on Glanzmann thrombasthenia in India – Clinical, laboratory and genetic aspects [PrincipalInvestigator- India] 2 As above & NIH, USA (B.Coller)
MOH, Israel
(U.Seligsohn)
Sept, 1997
8 Evaluation of low-dose continuous infusion of factor concentrates for
major surgery in severe haemophilia. [Principal Investigator]
2
2
Bayer Corp, USA
I.S.I spa, Italy
(Plasma derived factors)
Jan, 1999
Jun, 1999
10 Evaluation of low dose FEIBA for haemostasis during surgery USA for patients with haemophilia and high titre inhibitors [Principal Investigator] 2 Baxter Healthcare,
USA
Mar, 1999
11 Evaluation of amifostine for the prevention of cyclophosphamide induced haemorrhagic cystitis [Principal Investigator] 2 Fulford (India) Ltd Jan, 1997
12 A randomized trial of two schedules of subcutaneous HBV vaccination in patients with acute leukaemia [Co- Investigator] 2 Fluid Research,
CMC Hospital &Fulford (India) Ltd
April, 1999
13 Arsenic trioxide for the treatment of APML
[Co-Investigator]
1 Fluid Research,
CMC Hospital
Jan, 1998
14 BMT for thalassaemia in India – Setting up of an Advanced centre at CMC Hospital, Vellore
[Co-Investigator]
5 ICMR,
Govt. of India
Jan,1994
15 Thalassaemias in the Indian sub-continent – Clinical management and prevention
[Co-Investigator]
2 INSERM, France Aug,1995
  • Shima M, Thachil J, Nair SC, Srivastava A. Towards standardization of clot waveform analysis and recommendations for its clinical applications.J Thromb Haemost. 2013 Jul;11(7):1417-20.
  • Srivastava A, Brewer AK, Mauser-Bunschoten EP, Key NS, Kitchen S, Llinas A, Ludlam CA, Mahlangu JN, Mulder K, Poon MC, Street A; Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia. Guidelines for the management of hemophilia. Haemophilia. 2013 Jan;19(1):e1-47.
  • Mathews V, George B, Viswabandya A, Abraham A, Ahmed R, Ganapule A, Sindhuvi E, Lakshmi KM, Srivastava A. Improved Clinical Outcomes of High Risk β Thalassemia Major Patients Undergoing a HLA Matched Related Allogeneic Stem Cell Transplant with a Treosulfan Based Conditioning Regimen and Peripheral Blood Stem Cell Grafts. PLoS One. 2013 Apr 26;8(4):e61637.
  • Hareendran S, Balakrishnan B, Sen D, Kumar S, Srivastava A, Jayandharan GR. Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them. Rev Med Virol. 2013 Nov;23(6):399-413.
  • Sen D, Chapla A, Walter N, Daniel V, Srivastava A, Jayandharan GR. Nuclear factor (NF)-κB and its associated pathways are major molecular regulators of blood-induced joint damage in a murine model of hemophilia. J Thromb Haemost. 2013 Feb;11(2):293-306
  • Devi GS, Arora N, Rajkumar SV, Edison ES, Srivastava A, Jayandharan GR. Fluorescent PCR-based gene dose analysis for detection of deletion mutations in carriers of haemophilia. Haemophilia. 2013 Jul 16. doi: 10.1111/hae.12233.
  • Athiyarath R, Arora N, Fuster F, Schwarzenbacher R, Ahmed R, George B, Chandy M, Srivastava A, Rojas AM, Sanchez M, Edison ES. Two novel missense mutations in iron transport protein transferrin causing hypochromic microcytic anaemia and haemosiderosis: molecular characterization and structural implications. Br J Haematol. 2013 Nov;163(3):404-7.
  • Abraham A, Karathedath S, Varatharajan S, Markose P, Chendamarai E, Jayavelu AK, George B, Srivastava A, Mathews V, Balasubramanian P. ABCB6 RNA expression in leukemias-expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia. Ann Hematol. 2013 Jun 22.
  • Desire S, Mohanan EP, George B, Mathews V, Chandy M, Srivastava A, Balasubramanian P. A rapid & sensitive liquid chromatography- tandem mass spectrometry method for the quantitation of busulfan levels in plasma & application for routine therapeutic monitoring in haematopoietic stem cell transplantation. Indian J Med Res. 2013 Apr;137(4):777-84.
  • Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, Srivastava A, Jayandharan GR. Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. Sci Rep. 2013 May 13;6:1832.
  • Rajamanickam M, Michael R, Sampath V, John JA, Viswabandya A, Srivastava A. Should ice be used in the treatment of acute haemarthrosis in haemophilia? Haemophilia. 2013 Apr 16. doi: 10.1111/hae.12163.
  • Sumitha E, Jayandharan GR, Arora N, Abraham A, David S, Sankari Devi G,Shenbagapriya P, Nair SC, George B, Mathews V, Chandy M, Viswabandya A, Srivastava A. Molecular basis of quantitative fibrinogen disorders in 27 patients from India. Haemophilia. 2013 Apr 8. doi: 10.1111/hae.12143.
  • Sen D, Gadkari RA, Sudha G, Gabriel N, Kumar YS, Selot R, Samuel R, Rajalingam S, Ramya V, Nair SC, Srinivasan N, Srivastava A, Jayandharan GR. Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):104-16.doi: 10.1089/hgtb.2012.195
  • Gabriel N, Hareendran S, Sen D, Gadkari RA, Sudha G, Selot R, Hussain M, Dhaksnamoorthy R, Samuel R, Srinivasan N, Srivastava A, Jayandharan GR. Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):80-93.
  • Balakrishnan B, Sen D, Hareendran S, Roshini V, David S, Srivastava A, Jayandharan GR. Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS One. 2013;8(1):e53845. doi:10.1371/journal.pone.0053845.
  • Athiyarath R, Srivastava A, Edison ES. Molecular basis of primary iron overload in India and the role of serum-derived factors in hepcidin regulation. Ann Hematol. 2013 Jun;92(6):843-4.
  • Alkindi SS, Zadjali SA, Daar SA, Sindhuvi E, Wali YA, Pathare AV, Venugopal S, Lapoumeroulie C, Srivastava A, Krishnamoorthy R. A Stepwise α Thalassemia Screening Strategy in High Prevalence Areas. Eur J Haematol. 2013 May 13. doi:10.1111/ejh.12136.
  • Jain PP, Parihar M, Ahmed R, Abraham A, Vishwabandya A, George B, Mathews V, Srivastava A, Srivastava VM. Fluorescence in situ hybridization patterns of BCR/ABL1 fusion in chronic myelogenous leukemia at diagnosis. Indian J Pathol Microbiol. 2012 Jul-Sep;55(3):347-51.
  • Gorczyca ME, Nair SC, Jilma B, Priya S, Male C, Reitter S, Knoebl P, Gilbert JC, Schaub RG, Dockal M, McGinness KE, Pabinger I, Srivastava A. Inhibition of tissue factor pathway inhibitor by the aptamer BAX499 improves clotting of hemophilic blood and plasma. J Thromb Haemost. 2012 Aug;10(8):1581-1590.
  • Dargaud Y, Sorensen B, Shima M, Hayward C, Srivastava A, Negrier C. Global haemostasis and point of care testing. Haemophilia. 2012 Jul;18 Suppl 4:81-8.
  • Bharathan SP, Manian KV, Aalam SM, Palani D, Deshpande PA, Pratheesh MD, Srivastava A, Velayudhan SR. Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Biol Open. 2017 Jan 15;6(1):100-108. doi: 10.1242/bio.022111. PubMed PMID: 28089995.
  • Srivastava A, Shaji RV. Cure for thalassemia major: from allogeneic hematopoietic stem cell transplantation to gene therapy. Haematologica. 2016 Dec 1. pii: haematol.2015.141200. [Epub ahead of print] PubMed PMID: 27909215.
  • Varatharajan S, Panetta JC, Abraham A, Karathedath S, Mohanan E, Lakshmi KM, Arthur N, Srivastava VM, Nemani S, George B, Srivastava A, Mathews V, Balasubramanian P. Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia. Cancer Chemother Pharmacol. 2016 Nov;78(5):1051-1058. PubMed PMID: 27738808.
  • Ahmed R, Devasia AJ, Viswabandya A, Lakshmi KM, Abraham A, Karl S, Mathai J, Jacob PM, Abraham D, Srivastava A, Mathews V, George B. Long-term outcome following splenectomy for chronic and persistent immune thrombocytopenia (ITP) in adults and children : Splenectomy in ITP. Ann Hematol. 2016 Sep;95(9):1429-34. doi: 10.1007/s00277-016-2738-3. PubMed PMID: 27370992.
  • Garge S, Keshava SN, Moses V, Mammen S, Ahmed M, Chiramel GK, Cherian V, Manasseh N, George B, Mathews V, Abraham A, Viswabandya A, Srivastava A, Gibikote S. Role of endovascular embolization in treatment of acute bleeding complications in haemophilia patients. Br J Radiol. 2016 Jul 12:20151064. [Epub ahead of print] PubMed PMID: 27327402; PubMed Central PMCID: PMC5124877.
  • Ganapule A, Jain P, Nambiar FA, Korula A, Abraham A, Mammen J, George B, Mathews V, Srivastava A, Viswabandya A. Surgical procedures in patients with Glanzmann's thrombasthenia: case series and literature review. Blood Coagul Fibrinolysis. 2016 Jun 6. [Epub ahead of print] PubMed PMID: 27273143.
  • Deshpande PA, Srivastava VM, Mani S, Anandhan S, Meena J, Abraham A, Viswabandya A, George B, Srivastava A, Mathews V, Balasubramanian P. Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. Leuk Lymphoma. 2016 Oct;57(10):2481-4. doi: 10.3109/10428194.2016.1151512. PubMed PMID: 26942999.
  • Carcao M, Srivastava A. Factor VIII/factor IX prophylaxis for severe hemophilia. Semin Hematol. 2016 Jan;53(1):3-9. doi: 10.1053/j.seminhematol.2015.10.006. Review. PubMed PMID: 26805901.
  • Weiss DJ, Rasko JE, Cuende N, Ruiz MA, Ho HN, Nordon R, Wilton S, Dominici M, Srivastava A. Part 2: Making the "unproven" "proven". Cytotherapy. 2016 Jan;18(1):120-3. doi: 10.1016/j.jcyt.2015.11.005. PubMed PMID: 26719203.
  • Srivastava A, Mason C, Wagena E, Cuende N, Weiss DJ, Horwitz EM, Dominici M. Part 1: Defining unproven cellular therapies. Cytotherapy. 2016 Jan;18(1):117-9. doi: 10.1016/j.jcyt.2015.11.004. PubMed PMID: 26719202.
  • Thangakunam B, Christopher DJ, Mathews V, Srivastava A. Mesenchymal stromal stem cell therapy in advanced interstitial lung disease - Anaphylaxis and short-term follow-up. Lung India. 2015 Sep-Oct;32(5):486-8. doi: 10.4103/0970-2113.164156. PubMed PMID: 26628765; PubMed Central PMCID: PMC4587005.
  • Philip C, George B, Korula A, Srivastava A, Balasubramanian P, Mathews V. Treatment rates of paediatric acute myeloid leukaemia: a view from three tertiary centres in India - response to Gupta et al. Br J Haematol. 2016 Oct;175(2):347-349. doi: 10.1111/bjh.13857. PubMed PMID: 26627639.
  • Dominici M, Nichols K, Srivastava A, Weiss DJ, Eldridge P, Cuende N, Deans RJ, Rasko JE, Levine AD, Turner L, Griffin DL, O'Donnell L, Forte M, Mason C, Wagena E, Janssen W, Nordon R, Wall D, Ho HN, Ruiz MA, Wilton S, Horwitz EM, Gunter KC; 2013?2015 ISCT Presidential Task Force on Unproven Cellular Therapy.. Positioning a Scientific Community on Unproven Cellular Therapies: The 2015 International Society for Cellular Therapy Perspective. Cytotherapy. 2015 Dec;17(12):1663-6. doi: 10.1016/j.jcyt.2015.10.007. PubMed PMID: 26589750.
  • Manian KV, Aalam SM, Bharathan SP, Srivastava A, Velayudhan SR. Understanding the Molecular Basis of Heterogeneity in Induced Pluripotent Stem Cells. Cell Reprogram. 2015 Dec;17(6):427-40. doi: 10.1089/cell.2015.0013. PubMed PMID: 26562626.
  • Jayasree D, Shaji RV, George B, Mathews V, Srivastava A, Edison ES. Clinical, Hematological and Molecular Analysis of Homozygous Hb E (HBB: c.79G?>?A) in the Indian Population. Hemoglobin. 2016;40(1):16-9. doi: 10.3109/03630269.2015.1086880. PubMed PMID: 26554862.
  • Srivastava A. Inflammation is key to hemophilic arthropathy. Blood. 2015 Nov 5;126(19):2175-6. doi: 10.1182/blood-2015-09-665091. PubMed PMID: 26542253.
  • 17: Srivastava A. Current issues in hemophilia: recognizing clinical heterogeneity, replacement therapy, and outcome assessment. Semin Thromb Hemost. 2015 Nov;41(8):816-8. doi: 10.1055/s-0035-1564801. Review. PubMed PMID: 26540611.
  • 18: Blanchette VS, Srivastava A. Definitions in hemophilia: resolved and unresolved issues. Semin Thromb Hemost. 2015 Nov;41(8):819-25. doi: 10.1055/s-0035-1564800. Review. PubMed PMID: 26479892.
  • 19: Blobel CP, Haxaire C, Kalliolias GD, DiCarlo E, Salmon J, Srivastava A. Blood-induced arthropathy in hemophilia: mechanisms and heterogeneity. Semin Thromb Hemost. 2015 Nov;41(8):832-7. doi: 10.1055/s-0035-1564445. Review. PubMed PMID: 26451745.
  • Abraham A, Varatharajan S, Karathedath S, Philip C, Lakshmi KM, Jayavelu AK, Mohanan E, Janet NB, Srivastava VM, Shaji RV, Zhang W, Abraham A, Viswabandya A, George B, Chandy M, Srivastava A, Mathews V, Balasubramanian P. RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia. Pharmacogenomics. 2015 Jul;16(8):877-90. doi: 10.2217/pgs.15.44. PubMed PMID: 26083014.
  • Athiyarath R, Shaktivel K, Abraham V, Singh D, Bondu JD, Chapla A, George B, Srivastava A, Edison ES. Association of genetic variants with response to iron supplements in pregnancy. Genes Nutr. 2015 Jul;10(4):474. doi: 10.1007/s12263-015-0474-2. PubMed PMID: 26024779; PubMed Central PMCID: PMC4449341.
  • Philip C, George B, Ganapule A, Korula A, Jain P, Alex AA, Lakshmi KM, Sitaram U, Abubacker FN, Abraham A, Viswabandya A, Srivastava VM, Srivastava A, Balasubramanian P, Mathews V. Acute myeloid leukaemia: challenges and real world data from India. Br J Haematol. 2015 Jul;170(1):110-7. doi: 10.1111/bjh.13406. PubMed PMID: 25858293; PubMed Central PMCID: PMC4864448.
  • Chendamarai E, Ganesan S, Alex AA, Kamath V, Nair SC, Nellickal AJ, Janet NB, Srivastava V, Lakshmi KM, Viswabandya A, Abraham A, Aiyaz M, Mullapudi N, Mugasimangalam R, Padua RA, Chomienne C, Chandy M, Srivastava A, George B, Balasubramanian P, Mathews V. Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance. PLoS One. 2015 Mar 30;10(3):e0121912. doi: 10.1371/journal.pone.0121912. PubMed PMID: 25822503; PubMed Central PMCID: PMC4378855.
  • Doria AS, Keshava SN, Mohanta A, Jarrin J, Blanchette V, Srivastava A, Moineddin R, Kavitha ML, Hilliard P, Poonnoose P, Gibikote S. Diagnostic accuracy of ultrasound for assessment of hemophilic arthropathy: MRI correlation. AJR Am J Roentgenol. 2015 Mar;204(3):W336-47. doi: 10.2214/AJR.14.12501. PubMed PMID: 25714320.
  • Arora N, Nair S, Pai R, Nair S, Ahmed R, Abraham A, Viswabandya A, George B, Balasubramanian P, Srivastava A, Mathews V. V-raf murine sarcoma viral oncogene homolog B (BRAF) mutations in hairy cell leukaemia. Indian J Pathol Microbiol. 2015 Jan-Mar;58(1):62-5. doi: 10.4103/0377-4929.151190. PubMed PMID: 25673595.
  • Athiyarath R, George B, Abraham A, Viswabandya A, Srivastava A, Edison ES. Genetic modifiers of secondary iron overload in beta thalassemia major. Blood Cells Mol Dis. 2015 Mar;54(3):242-3. doi: 10.1016/j.bcmd.2014.12.006. PubMed PMID: 25601433.
  • Mathews V, Srivastava A, Chandy M. Allogeneic stem cell transplantation for thalassemia major. Hematol Oncol Clin North Am. 2014 Dec;28(6):1187-200. doi: 10.1016/j.hoc.2014.08.009. Review. PubMed PMID: 25459187.
  • Rajagopal V, Sundaresan L, Rajkumar AP, Chittybabu C, Kuruvilla A, Srivastava A, Balasubramanian P, Jacob KS, Jacob M. Genetic association between the DRD4 promoter polymorphism and clozapine-induced sialorrhea. Psychiatr Genet. 2014 Dec;24(6):273-6. doi: 10.1097/YPG.0000000000000058. PubMed PMID: 25304228.
  • Athiyarath R, George B, Mathews V, Srivastava A, Edison ES. Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in ?-thalassemia. Ann Hematol. 2014 Dec;93(12):2093-5. doi: 10.1007/s00277-014-2113-1. PubMed PMID: 24867648.
  • Mayuranathan T, Rayabaram J, Das R, Arora N, Edison ES, Chandy M, Srivastava A, Velayudhan SR. Identification of rare and novel deletions that cause (??)0-thalassaemia and hereditary persistence of foetal haemoglobin in Indian population. Eur J Haematol. 2014 Jun;92(6):514-20. doi: 10.1111/ejh.12276. PubMed PMID: 24471888.
  • George B, Mathews V, Lakshmi KM, Melinkeri S, Sharma A, Viswabandya A, Sharma S, Das S, Ahmed R, Abraham A, Nair V, Apte S, Chandy M, Srivastava A. The use of a fludarabine-based conditioning regimen in patients with severe aplastic anemia--a retrospective analysis from three Indian centers. Clin Transplant. 2013 Nov-Dec;27(6):923-9. doi: 10.1111/ctr.12263. PubMed PMID: 24304374.
  • Hareendran S, Balakrishnan B, Sen D, Kumar S, Srivastava A, Jayandharan GR. Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them. Rev Med Virol. 2013 Nov;23(6):399-413. doi: 10.1002/rmv.1762. Review. PubMed PMID: 24023004.
  • Athiyarath R, Arora N, Fuster F, Schwarzenbacher R, Ahmed R, George B, Chandy M, Srivastava A, Rojas AM, Sanchez M, Edison ES. Two novel missense mutations in iron transport protein transferrin causing hypochromic microcytic anaemia and haemosiderosis: molecular characterization and structural implications. Br J Haematol. 2013 Nov;163(3):404-7. doi: 10.1111/bjh.12487. PubMed PMID: 23888904.
  • Abraham A, Karathedath S, Varatharajan S, Markose P, Chendamarai E, Jayavelu AK, George B, Srivastava A, Mathews V, Balasubramanian P. ABCB6 RNA expression in leukemias--expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia. Ann Hematol. 2014 Mar;93(3):509-12. doi: 10.1007/s00277-013-1821-2. PubMed PMID: 23793916.
  • Desire S, Mohanan EP, George B, Mathews V, Chandy M, Srivastava A, Balasubramanian P. A rapid & sensitive liquid chromatography- tandem mass spectrometry method for the quantitation of busulfan levels in plasma & application for routine therapeutic monitoring in haematopoietic stem cell transplantation. Indian J Med Res. 2013 Apr;137(4):777-84. PubMed PMID: 23703347; PubMed Central PMCID: PMC3724260.
  • Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, Srivastava A, Jayandharan GR. Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. Sci Rep. 2013;3:1832. doi: 10.1038/srep01832. PubMed PMID: 23665951; PubMed Central PMCID: PMC3652085.
  • Mathews V, George B, Viswabandya A, Abraham A, Ahmed R, Ganapule A, Sindhuvi E, Lakshmi KM, Srivastava A. Improved clinical outcomes of high risk ? thalassemia major patients undergoing a HLA matched related allogeneic stem cell transplant with a treosulfan based conditioning regimen and peripheral blood stem cell grafts. PLoS One. 2013 Apr 26;8(4):e61637. doi: 10.1371/journal.pone.0061637. PubMed PMID: 23637873; PubMed Central PMCID: PMC3637210.
  • Sen D, Gadkari RA, Sudha G, Gabriel N, Kumar YS, Selot R, Samuel R, Rajalingam S, Ramya V, Nair SC, Srinivasan N, Srivastava A, Jayandharan GR. Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):104-16. doi: 10.1089/hgtb.2012.195. PubMed PMID: 23442071; PubMed Central PMCID: PMC3732127.
  • Gabriel N, Hareendran S, Sen D, Gadkari RA, Sudha G, Selot R, Hussain M, Dhaksnamoorthy R, Samuel R, Srinivasan N, Srivastava A, Jayandharan GR. Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):80-93. doi: 10.1089/hgtb.2012.194. PubMed PMID: 23379478; PubMed Central PMCID: PMC3732126.
  • Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M, Jacob KS. Association between CYP1A2 gene single nucleotide polymorphisms and clinical responses to clozapine in patients with treatment-resistant schizophrenia. Acta Neuropsychiatr. 2013 Feb;25(1):2-11. doi: 10.1111/j.1601-5215.2012.00638.x. PubMed PMID: 26953068.
  • Balakrishnan B, Sen D, Hareendran S, Roshini V, David S, Srivastava A, Jayandharan GR. Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS One. 2013;8(1):e53845. doi: 10.1371/journal.pone.0053845. PubMed PMID: 23320106; PubMed Central PMCID: PMC3540029.
  • Jain PP, Parihar M, Ahmed R, Abraham A, Vishwabandya A, George B, Mathews V, Srivastava A, Srivastava VM. Fluorescence in situ hybridization patterns of BCR/ABL1 fusion in chronic myelogenous leukemia at diagnosis. Indian J Pathol Microbiol. 2012 Jul-Sep;55(3):347-51. doi: 10.4103/0377-4929.101742. PubMed PMID: 23032829.
  • Varatharajan S, Abraham A, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P. Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia. Eur J Clin Pharmacol. 2012 Dec;68(12):1577-86. doi: 10.1007/s00228-012-1291-9. PubMed PMID: 22562609.
  • Sabapathy V, Ravi S, Srivastava V, Srivastava A, Kumar S. Long-term cultured human term placenta-derived mesenchymal stem cells of maternal origin displays plasticity. Stem Cells Int. 2012;2012:174328. doi: 10.1155/2012/174328. PubMed PMID: 22550499; PubMed Central PMCID: PMC3329664.
  • 45: Peter CV, Chakrapani A, Shah S, Shah A, Srivastava A. Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules. Indian J Dermatol. 2012 Jan;57(1):45-7. doi: 10.4103/0019-5154.92677. PubMed PMID: 22470209; PubMed Central PMCID: PMC3312657.
  • Patkar N, Alex AA, B B, Ahmed R, Abraham A, George B, Vishwabandya A, Srivastava A, Mathews V. Standardizing minimal residual disease by flow cytometry for precursor B lineage acute lymphoblastic leukemia in a developing country. Cytometry B Clin Cytom. 2012 Jul;82(4):252-8. doi: 10.1002/cyto.b.21017. PubMed PMID: 22467604.
  • Chendamarai E, Balasubramanian P, George B, Viswabandya A, Abraham A, Ahmed R, Alex AA, Ganesan S, Lakshmi KM, Sitaram U, Nair SC, Chandy M, Janet NB, Srivastava VM, Srivastava A, Mathews V. Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Blood. 2012 Apr 12;119(15):3413-9. doi: 10.1182/blood-2011-11-393264. PubMed PMID: 22374701.
  • Jayandharan GR, Srivastava A, Srivastava A. Role of molecular genetics in hemophilia: from diagnosis to therapy. Semin Thromb Hemost. 2012 Feb;38(1):64-78. doi: 10.1055/s-0031-1300953. Review. PubMed PMID: 22314605.
  • Abraham A, Varatharajan S, Abbas S, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P. Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia. Pharmacogenomics. 2012 Feb;13(3):269-82. doi: 10.2217/pgs.11.149. PubMed PMID: 22304580.
  • Sellathamby S, Lakshmi KM, Busson M, Viswabandya A, George B, Mathews V, Chandy M, Charron D, Krishnamoorthy R, Tamouza R, Srivastava A. Polymorphisms in the immunoregulatory genes are associated with hematopoietic recovery and increased susceptibility to bacterial infections in patients with thalassaemia major undergoing matched related hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2012 Aug;18(8):1219-26. doi: 10.1016/j.bbmt.2012.01.011. PubMed PMID: 22252124.
  • Balasubramanian P, Chendamarai E, Markose P, Fletcher L, Branford S, George B, Mathews V, Chandy M, Srivastava A. International reporting scale of BCR-ABL1 fusion transcript in chronic myeloid leukemia: first report from India. Acta Haematol. 2012;127(3):135-42. doi: 10.1159/000334716. PubMed PMID: 22249155.

Education And Training

Duration Institution Particulars Of Work Done
1976-1982 Christian Medical College, Vellore Undergraduate education in Medicine
1983-1986 Christian Medical College, Vellore Postgraduate training in General Medicine
1987-1989 Christian Medical College, Vellore Sub-specialty experience in Haematology
1990-1993 Inst of Clin Path & Med Res Westmead Centre,
Sydney, Australia
Training in Haematology
(Clinical & Laboratory)
1991(Apr-Jul) Red Cross Blood Trans Service
Sydney, Australia
Transfusion Medicine

Professional Qualifications

Degree University / College Subject Year
MBBS University of Madras, India MEDICINE 1983
MD University of Madras, India GENERAL MEDICINE 1987
FRACP Royal Australasian College of Physicians INTERNAL MEDICINE
(Subspecialty – Haematology)
1993
FRCPA Royal Australasian College of Physicians HAEMATOLOGY 1993
FRCP (Hon) Royal College of Physicians, UK HAEMATOLOGY 2004

Current Positions

  • Professor of Medicine, Department of Haematology, Christian Medical College, Vellore, India
  • Head, Center for Stem Cell Research, Christian Medical College, Vellore, India
  • Chair, Asia Pacific Hemophilia Working Group
  • Vice-Chair, Asia Pacific Blood and Marrow Transplantation Group

Past Positions

  • Head, Department of Haematology, Christian Medical College, Vellore, India (2006-2014)
  • Chair, National Apex Committee, Stem Cell Research & Therapy, Department of Health Research, MOH, Govt. of India (2010-2016)
  • First Ida Scudder Research Chair, Christian Medical College, Vellore (2012-2016)
  • Vice President, Medical, World Federation of Hemophilia (2012-2014)
  • Vice-Chair, Center for International Blood and Marrow Transplantation Research (2011-2014)
  • Vice President, Communications and Public Policy, World Federation of Hemophilia (2010-12)
  • Chair, International Ext. Quality Assessment Scheme, World Federation of Hemophilia (2008 – 2012)
  • Co-Chair, Taskforce on Stem Cell Research and Reg. Med., Department of Biotechnology, Govt. of India (2006-2012)
  • Co-Chair, Clinical Translation Committee, International Society for Stem Cell Research (2008-2011)
  • Co-chair, FVIII/IX subcommittee, SSC of International Society on Thrombosis & Hemostasis (2001-2006)
  • Chair, FVIII/IX subcommittee, SSC of International Society on Thrombosis & Hemostasis (2006-2010)

Previous Appointments

1987-1988 Junior Lecturer Department of Haematology
1988-1991 Lecturer Christian Medical College, Vellore
1991-1995 Reader Affiliated to the
1995-1996 Associate Professor Tamil Nadu MGR Medical University,
1996 onwards Professor Chennai, India

Honours Received

  • 2002 :Rev. Fr. Lourdu M. Yeddanapalli Gold Medal for the best researcher, Christian Medical College, Vellore
  • 2004: Manorma Sapre Oration – Indian Society of Hematology and Blood Transfusion
  • 2006: Henri Chaigneau Medal – XVIth International prize of the French Association of Haemophiliacs
  • 2007: J G Parikh Oration – Indian Society of Haematology and Transfusion Medicine
  • 2009: L R Sarin Oration – SMS Medical College, Jaipur, Rajastahan.
  • 2009: Das Gupta Oration – Indian Academy of Neurology
  • 2010: Pia Glas Greenwalt Memorial Lecture – International Society on Thrombosis and Haemostasis
  • 2012 : Inga Marie Nilsson Award – World Federation of Hemophilia, Montreal, Canada
  • 2012 : Ida Scudder Research Chair, Christian Medical College, Vellore (on going).
  • 2012: Ramalingaswamy Oration – Institute of Liver and Biliary Sciences, New Delhi
  • 2016 : Malathi Sathe Oration of the Indian Society of Haematology & Blood Transfusion

Membership of Professional Bodies

  • Indian Society of Haematology and Blood Transfusion
  • International Society on Thrombosis Haemostasis
  • American Society of Hematology
  • International Society for Stem Cell Research

World Health Organization Assignments

  • Haemophilia care in the developing world – June,1997. Represented developing countries in this joint WHO / WFH meeting
  • Impact, prevention and control of von Willebrand disease – October, 1998. Represented developing countries in this joint WHO / ISTH meeting
  • Delivery of Haemophilia Treatment – February, 2002. Represented developing countries in this joint WHO / WFH meeting

Advisory Positions

  • Associate Editor, Seminars in Thrombosis and Hemostasis
  • Associate Editor, Frontiers in Alloimmunity and Transplantation
  • Member, Editorial Board of HAEMOPHILIA
  • Member, Editorial Board, Journal of Thrombosis and Hemostasis
  • Member, Editorial Board, Blood Coagulation and Fibrinolysis