FACULTY

Ms. Ansu Abu Alex

Ms. Ansu Abu Alex

  • Investigating the impact of arsenic trioxide on the immune and cellular response in acute promyelocytic leukemia patients and in APL mouse model
  • Use of flow cytometry in the diagnosis of leukemia, lymphoma, minimal residual disease and other immunological and hematological disorders

Evaluation of cellular and immune response in acute promyelocytic leukemia treated with arsenic trioxide.

  • Rationale and efficacy of proteasome inhibitor combined with arsenic trioxide in the treatment of acute promyelocytic leukemia. Ganesan, A A Alex, E Chendamarai, N Balasundaram, H K Palani, S David, U Kulkarni, M Aiyaz, R Mugasimangalam, A Korula, A Abraham, A Srivastava, R A Padua, C Chomienne, B George, P Balasubramanian and V Mathews. Leukemia. 2016 Nov;30(11):2169-2178.
  • Leukocyte Adhesion Deficiency-I: Clinical and Molecular Characterization in an Indian Population. Deshpande P, Kathirvel K, Alex AA, Korula A, George B, Shaji RV, Mathews V. Indian J Pediatr. 2016 Aug;83(8):799-804
  • Acute myeloid leukaemia: challenges and real world data from India. Philip C, George B, Ganapule A, Korula A, Jain P, Alex AA, Lakshmi KM, Sitaram U, Abubacker FN, Abraham A, Viswabandya A, Srivastava VM, Srivastava A, Balasubramanian P, Mathews V. Br J Haematol. 2015 Jul;170(1):110-7
  • Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance. Chendamarai E, Ganesan S, Alex AA, Kamath V, Nair SC, Nellickal AJ, Janet NB, Srivastava V, Lakshmi KM, Viswabandya A, Abraham A, Aiyaz M, Mullapudi N, Mugasimangalam R, Padua RA, Chomienne C, Chandy M, Srivastava A, George B, Balasubramanian P, Mathews V. PLoS One. 2015 Mar 30; 10(3):e0121912
  • DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies. Carole le Pogam, Satya Patel, Petra Gorombei, Laura Guerenne, Patricia Krief, Nader Omidvar, Nilgun Tekin, Elena Bernasconi, Flore Sicre, Marie-Hélène Schlageter, Martine Chopin, Maria-Elena Noguera, Ansu Abu, Vikram Mathews, Robert West, Marika Pla, Pierre Fenaux, Christine Chomienne, and Rose Ann Padua, Oncotarget. 2015 Oct 20;6(32):32494-508
  • pVAX14DNA-mediated add-on immunotherapy combined with arsenic trioxide and all-trans retinoic acid targeted therapy effectively increases the survival of acute promyelocytic leukemia mice. S Patel, L Guerenne, P Gorombei, N Omidvar, M-H Schlageter, AA Alex, S Ganesan, R West, L Adès, V Mathews, P Krief, M Pla, P Fenaux, C Chomienne and RA Padua, Blood Cancer J. 2015 Dec 11;5:e374
  • Early T cell precursor lymphoid blast crisis of chronic myeloid leukemia - A novel transformation. Senapati J, Devasia AJ, Alex AA, George B., Hematol Oncol Stem Cell Ther. 2015 Mar;8(1):43-6
  • Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Chendamarai E, Balasubramanian P, George B, Viswabandya A, Abraham A, Ahmed R, Alex AA, Ganesan S, Lakshmi KM, Sitaram U, Nair SC, Chandy M, Janet NB, Srivastava VM, Srivastava A, Mathews V. Blood. 2012 Apr 12;119(15):3413-9.
  • Standardizing minimal residual disease by flow cytometry for precursor B lineage acute lymphoblastic leukemia in a developing country. Patkar N, Alex AA, B B, Ahmed R, Abraham A, George B, Vishwabandya A, Srivastava A, Mathews V. Cytometry B Clin Cytom. 2012 Jul;82(4):252-8.
  • Clinicopathological features of hepatosplenic T cell lymphoma: a single centre experience from India. Patkar N, Nair S, Alex AA, Parihar M, Manipadam MT, Arora N, Ahmed R, Abraham A, George B, Viswabandya A, Srivastava V, Srivastava A, Mathews V. Leuk Lymphoma. 2012 Apr;53(4):609-15
  • Quantitative and Qualitative Effects of Arsenic trioxide on Natural Killer Cells Ansu Abu Alex, Saravanan Ganesan, Hamenth KumarPalani, Nithya Balasundaram, Kavitha M Lakshmi, Sachin David, Biju George, Aby Abraham, Alok Srivastava, Rose Ann Padua, Christine Chomienne, Poonkuzhali Balasubramanian and Vikram Mathews (submitted).

Education

Degree University / College Year
PhD Biological Sciences
Department of Hematology,
Guide: Dr. Vikram Mathews, HOD,
Christian Medical College, Vellore, India
Jan 2011 – Mar 2017
Thesis Submitted
MSc Biomedical Genetics
VIT University,
Vellore Institute of Technology, Vellore, Tamil Nadu, India
2006 - 2008
BSc Biotechnology
Kerala University,
Marthoma College of Science and Technology, Kerala, India
2003 - 2006

Position and Employment

Lecturer Department of Hematology,
Christian Medical College, Vellore, India
Jan 2011 – Mar 2017
Thesis Submitted
Senior Demonstrator Department of Hematology,
Christian Medical College, Vellore, India
2009-2012

Membership

  • The International Society for Advancement of Cytometry (ISAC)

Honours And Awards

  • BEST ABSTRACT award at 7th International Hematologic malignancies Conference: BTG 2016, held at Guangzou, China (oral presentation).
  • Dr. J .C Patel Best Paper Award for the work entitled 'NK cell mediated cytotoxicity against malignant promyelocytes enhanced by arsenic trioxide and its potential clinical relevance' at the 54th Annual Conference of Indian Society of Haematology and Blood Transfusion held in Mumbai 2013 (oral presentation).
  • Presented the work entitled 'Patterns of Immune Reconstitution in Patients with Acute Promyelocytic Leukemia Treated with Single Agent Arsenic Trioxide and Its Impact on Time to Molecular Remission' at the 6th International symposium on Acute Promyelocytic Leukemia held in Rome 2013 (oral presentation) (travel support from CSIR).
  • ASH abstract achievement award for the abstract 'NK cell mediated cytotoxicity against malignant promyelocytes enhanced by arsenic trioxide and its potential clinical relevance', at American Society of Hematology Annual Meeting at New Orleans 2013 (poster presentation).
  • ASH abstract achievement award for 'Patterns of immune reconstitution in patients with acute promyelocytic leukemia treated with single agent arsenic trioxide and its impact on time to molecular remission' at American Society of Hematology Annual Meeting at Atlanta 2012 (poster presentation).
  • Awarded 3rd prize at the Annual research day programme, CMC, Vellore, 2012 (poster presentation).
  • Presented 'Immunophenotypic characterization and quantification of Myeloid derived suppressor cells in patients with leukemia' for ISHTM Conference, Kolkata 2010 (oral presentation).
  • Qualified GATE examination 2009.
  • Awarded gold medal by Kerala University for obtaining First Rank in B.Sc. (Biotechnology), 2003-2006.
  • Awarded merit scholarship from VIT University, Vellore for academic excellence (2006-2008).
  • Obtained scholarship from All India Association for Christian Higher Education, 2003-2004.
  • Awarded Certificate of Merit from Santhikendram, Anchal, for CBSE 10th , 2001.